机构地区:[1]南方医科大学附属第十医院,广东东莞523059
出 处:《现代中西医结合杂志》2023年第10期1330-1333,1340,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine
基 金:广东省中医药局资助项目(20181263);东莞市社会科技发展(重点)项目(202050715001210);东莞市2021年李轩名中医药专家传承工作室建设项目。
摘 要:目的观察补肾疏肝中药对男性迟发性性腺功能减退症(LOH)患者血清胰岛素样生长因子-1(IGF-1)、胰岛素样因子3(INSL3)的影响,探索补肾疏肝法治疗LOH的可能机制。方法选择2019年3月-2022年3月南方医科大学附属第十医院治疗的90例LOH肾虚肝郁证患者,根据就诊先后按随机数字表法将患者分为试验组和对照组,每组45例。试验组以补肾疏肝法治疗,药用还少丹合逍遥丸改煎剂加减内服,每日1剂;对照组给予十一酸睾酮胶囊口服,80 mg/次,2次/d,4周后用量减至40 mg/次,2次/d。2组均用药12周。观察比较2组患者治疗前后中老年男子部分雄激素缺乏综合征(PADAM)评分及血清睾酮(T)、促卵泡生成素(FSH)、黄体生成素(LH)、IGF-1及INSL3水平。结果与治疗前比较,2组患者治疗后PADAM评分均明显降低(P均<0.05),且试验组明显低于对照组(P<0.05);治疗后试验组患者血清T、血清IGF-1水平均明显升高(P均<0.05),FSH、LH水平均明显降低(P均<0.05),且试验组血清T水平明显低于对照组(P<0.05),IGF-1水平明显高于对照组(P<0.05);治疗后对照组患者血清T水平明显升高(P<0.05),IGF-1、FSH、LH水平均无明显变化(P均>0.05);2组INSL3水平均无明显变化(P均<0.05)。结论补肾疏肝法可能通过提升血清IGF-1、促进T合成及分泌,延缓INSL3下降,保护睾丸功能,有效治疗LOH。Objective It is to observe the effect of traditional Chinese medicine for tonifying the kidney and soothing the liver on serum insulin-like growth factor-1(IGF-1)and insulin-like factor 3(INSL3)in patients with late-onset hypogondism(LOH)in males,to explore the possible mechanism of tonifying the kidney and soothing the liver in the treatment of LOH.Methods Ninety patients with LOH of syndrome of kidney deficiency and liver depression treated in the Tenth Hospital Affiliated to Southern Medical University from March 2019 to March 2022 were selected,and randomly divided into experimental group and control group according to the order of consultation and randomized numerical table method,with 45 cases in each group.The experimental group was treated with therapy for tonifying the kidney and soothing the liver which was the modified decoction of Huanshao pills and Xiaoyao pills,one decoction daily,the control group was treated with testosterone undecanoate by oral administration,80 mg per time,twice daily,and decreased to 40mg per time,twice daily.Both groups were treated for 12 weeks.The scores of partial androgen deficiency of the aging male(PADAM)and the levels of serum testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH),IGF-1 and INSL3 of the patients in the two groups were observed and compared before and after treatment.Results The PADAM scores of the patients in the two groups after treatment were significantly lower than those before treatment(both P<0.05),and the decrease of the scores of experimental group was more significant than that of the control group(P<0.05);the levels of serum T and IGF-1 of the patients in the experimental group were significantly increased,and the levels of FSH and LH were significantly decreased after treatment(all P<0.05),the level of serum T of the experimental group was significantly lower while the level of IGF-1 level was significantly higher than that of the control group after treatment(both P<0.05);the level of serum T of the patients in the control
关 键 词:补肾疏肝法 迟发性性腺功能减退症 睾酮 胰岛素样生长因子-1 胰岛素样因子3
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