拮抗剂添加日血清LH水平不同的不孕症患者GnRH-ant灵活方案促排卵后IVF-ET移植效果观察  

Observation on effect of IVF-ET transplantation after GnRH-ant flexible protocol for ovulation induction in infertile patients with different serum LH levels on the day of antagonist addition

作　　者：马玎[1] 曲庆兰[1] 张伟[1] 王梅梅 郝苗 刘雪梅[1] MA Ding;QU Qinglan;ZHANG Wei;WANG Meimei;HAO Miao;LIU Xuemei(Department of Reproductive Medicine,Yantai Yuhuangding Hospital,Qingdao University,Yantai 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院生殖医学科,山东烟台264000

出　　处：《山东医药》2023年第18期11-14,共4页Shandong Medical Journal

基　　金：山东省医药卫生科技计划发展项目(202005030944)。

摘　　要：目的比较拮抗剂添加日不同水平的血清促黄体生成素(luteinizing hormone,LH)在促性腺激素释放激素拮抗剂(gonadotropin-releasing hormone antagonist,GnRH-ant)灵活方案中对不孕症患者体外受精—胚胎移植(In Vitro Fertilization and Embryo Transfer,IVF-ET)妊娠结局的影响。方法607例接受灵活的拮抗剂方案的不孕症患者,根据拮抗剂添加日血清LH水平分为LH<10 mIU/mL 189例(A组)、10 mIU/mL≤LH<20 mIU/mL 285例(B组)及LH≥20 mIU/mL 133例(C组)。观察并记录三组患者获卵数、卵子成熟率、2PN受精率、卵裂率、优质胚胎率、鲜胚种植率、新鲜周期移植率、临床妊娠率、流产率及活产率。结果与A组比较,B组患者卵裂率、优质胚胎率及活产率高,流产率低(P均<0.05);与B组比较,C组卵裂率、优质胚胎率及活产率低,流产率高(P均<0.05)。结论拮抗剂添加日血清10 mIU/mL≤LH<20 mIU/mL时不孕症患者的促排卵效果好,IVF-ET妊娠结局较好。Objective To compare the effects of different levels of serum luteinizing hormone(LH)on the day of an⁃tagonist addition on the pregnancy outcomes of infertile patients undergoing in vitro fertilization-embryo transfer(IVF-ET)with gonadotropin-releasing hormone antagonist(GnRH-ant)flexible protocol.Methods Totally 607 infertile patients receiving antagonist flexible protocol treatment were divided into the group A of 189 cases with LH<10 mIU/mL,group B of 285 cases with 10 mIU/mL≤LH<20 mIU/mL,and group C of 133 cases with LH≥20 mIU/mL according to the se⁃rum LH level on the day of antagonist addition.We observed and recorded the number of oocytes obtained,oocytes matura⁃tion rate,2PN fertilization rate,the cleavage rate,high-quality embryo rate,fresh embryo implantation rate,fresh cycle transfer rate,clinical pregnancy rate,miscarriage rate,and live birth rate in patients of three groups.Results Com⁃pared with patients in the group A,the patients in the group B had higher cleavage rate,high-quality embryo rate,and live birth rate,while lower miscarriage rate(all P<0.05).Compared with the group B,group C had lower cleavage rate,highquality embryo rate,and live birth rate,but higher miscarriage rate(all P<0.05).Conclusions Serum with 10 mIU/mL≤LH<20 mIU/mL on the day of antagonist addition resulted in better ovulation in promoting effects and better pregnancy outcomes in IVF-ET on infertile patients.

关 键 词：促黄体生成素 促性腺激素释放激素拮抗剂 促性腺激素释放激素拮抗剂灵活方案 体外受精—胚胎移植 妊娠结局 

分 类 号：R711.75[医药卫生—妇产科学]