^(18)F-FDG PET/CT引导经皮肺穿刺活检术在肺占位病变诊断中的应用  

Application of ^(18)F-FDG PET/CT-guided percutaneous lung biopsy in the diagnosis of pulmonary space-occupying lesions

作　　者：候青青 胡斌[1,2] 黄诚[1,2] 毛秋粉[1,2] 郑艳 罗要国[1,2] HOU Qingqing;HU Bin;HUANG Cheng;MAO Qiufen;ZHENG Yan;LUO Yaoguo(不详;Clinical Medical College,Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南洛阳471003 [2]河南科技大学第一附属医院核医学科

出　　处：《山东医药》2023年第18期30-33,共4页Shandong Medical Journal

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200572)。

摘　　要：目的观察^(18)F-FDG正电子发射计算机断层显像(PET)/电子计算机断层扫描(CT)引导经皮肺穿刺活检术在肺占位病变诊断中的应用效果。方法325例疑似肺占位病变患者,其中102例行18F-FDG PET/CT高代谢靶区定位后经皮肺穿刺活检术(观察组)、单纯CT指导下肺内病灶穿刺患者223例(对照组),以穿刺活检组织病理检查结果结合随访结果为临床最终诊断(金标准),测算^(18)F-FDG PET/CT定位后经皮肺穿刺活检术后穿刺活检组织病理学诊断的检出率、敏感度、特异度和准确率。结果①96例观察组的临床最终诊断结果为恶性病变84例、良性病变12例。96例患者的穿刺活检组织病理结果为良性病变14例、恶性病变82例,14例良性病变中临床最终诊断为恶性病变2例、良性病变12例。196例对照组的临床最终诊断结果为恶性病变162例、良性病变34例。196例患者的穿刺活检组织病理结果为良性病变61例、恶性病变135例,61例良性病变中临床最终诊断为恶性病变27例、良性病变34例。②观察组患者病理学诊断的检出率、敏感度、特异度和准确率分别为94.1%(96/102)、97.6%(82/84)、100%(12/12)、97.9%(94/96),对照组患者的检出率、敏感度、特异度和准确率分别为87.8%(196/223)、83.3%(135/162)、100%(34/34)、86.2%(169/196),与对照组比较,观察组患者病理学诊断的敏感度及准确率均较高(χ^(2)分别为10.856、9.848,P均<0.01)。结论相比于单纯CT引导,^(18)F-FDG PET/CT高代谢靶区定位可提高穿刺活检术中的定位及穿刺活检组织病理学诊断的准确性。Objective To observe the application of ^(18)F-FDG positron emission computed tomography(PET)/elec⁃tronic computed tomography(CT)-guided percutaneous lung biopsy in the diagnosis of pulmonary space-occupying le⁃sions.Methods Totally 325 patients with suspected pulmonary space-occupying lesions,including 102 patients who un⁃derwent percutaneous lung biopsy after ^(18)F-FDG PET/CT high metabolism target localization(observation group)and 223 patients who underwent lung biopsy guided solely by CT(control group)were selected.Based on the pathological examina⁃tion results of biopsy tissue combined with follow-up results as the clinical final diagnosis(gold standard),and after 18FFDG PET/CT localization,the detection rate,sensitivity,specificity,and accuracy of pathological diagnosis of biopsy tis⁃sues after percutaneous lung biopsy were calculated.Results①The final clinical diagnosis showed that there were 84 cases of malignant lesions and 12 cases of benign lesions in 96 patients of the observation group.The pathological results of 96 patients´biopsy tissue showed there were 14 cases of benign lesions and 82 cases of malignant lesions.Among the 14 benign lesions,2 were clinically diagnosed as malignant lesions and 12 were benign lesions.The final clinical diagnosis showed that there were 162 cases of malignant lesions and 34 cases of benign lesions in 196 patients of the control group.The pathological results of biopsy tissues from 196 patients showed there were 61 cases of benign lesions and 135 cases of malignant lesions.Among the 61 cases of benign lesions,27 were clinically diagnosed as malignant lesions and 34 were benign lesions.②The detection rate,sensitivity,specificity,and accuracy of pathological diagnosis in the observation group were 94.1%(96/102),97.6%(82/84),100%(12/12),and 97.9%(94/96),respectively.The detection rate,sensitivity,specificity,and accuracy in the control group were 87.8%(196/223),83.3%(135/162),100%(34/34),and 86.2%(169/196),respectively.Compared with the control group,the

关 键 词：^(18)F-FDG正电子发射计算机断层显像/电子计算机断层扫描 经皮肺穿刺活检术 肺占位病变 肺肿瘤 

分 类 号：R563[医药卫生—呼吸系统]