注射用红花黄色素联合新活素治疗心力衰竭的效果观察  

Effect Observation of Safflower Yellower for Injection Combined with Xinhuosu in Treatment of Heart Failure

作　　者：顾晶 杨丽 Gu Jing;Yang Li(Cardiovascular Department,The Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,Liaoning Province,China;Emergency Department,The Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,Liaoning Province,China)

机构地区：[1]锦州医科大学附属第三医院心血管内科,辽宁锦州121000 [2]锦州医科大学附属第三医院急诊科,辽宁锦州121000

出　　处：《中国社区医师》2023年第19期21-23,共3页Chinese Community Doctors

摘　　要：目的:探讨注射用红花黄色素联合新活素(冻干重组人脑利钠肽,rhBNP)治疗心力衰竭的临床效果。方法:选取2021年1月—2023年5月锦州医科大学附属第三医院收治的60例心力衰竭患者作为研究对象,随机分为观察组、对照A组和对照组B组,各20例。对照A组给予注射用红花黄色素治疗,对照B组给予新活素治疗,观察组给予注射用红花黄色素联合新活素治疗。对比三组心功能、N末端脑利钠前体(NT-proBNP)水平及治疗效果。结果:治疗后,观察组左室射血分数(LVEF)、舒张早期充盈峰速度/舒张晚期充盈峰速度(E/A)高于对照A组和对照组B组,NT-proBNP低于对照A组和对照组B组,差异有统计学意义(P<0.001);对照A组和对照组B组LVEF比较,差异无统计学意义(P>0.05);对照组B组E/A高于对照A组,NT-proBNP低于对照A组,差异有统计学意义(P<0.001)。观察组治疗总有效率高于对照A组和对照B组,对照B组治疗总有效率高于对照A组,差异有统计学意义(P<0.05)。结论:注射用红花黄色素联合新活素治疗心力衰竭的效果显著,可提高患者LVEF、E/A,降低NT-proBNP水平,值得临床推广。Objective:To explore the clinical effect of safflower yellower for injection combined with Xinhuosu(lyophilized recombinant human brain natriuretic peptide,rhBNP)in the treatment of heart failure.Methods:Sixty patients with heart failure treated in the Third Affiliated Hospital of Jinzhou Medical University from January 2021 to May 2023 were selected as the study subjects.They were randomly divided into an observation group,a control group A,and a control group B,with 20 cases in each group.The control group A was treated with safflower yellower for injection,control group B was treated with Xinhuosu,and observation group was treated with safflower yellower for injection and Xinhuosu.The cardiac function,N-terminal pro-B-type natriuretic peptide(NT-proBNP)level and treatment effect were compared among three groups.Results:After treatment,the left ventricular ejection fraction(LVEF),early to late diastolic transmitral flow velocity(E/A)in the observation group were higher than those in the control group A and control group B,and NT-proBNP in the observation group was lower than that in control group A and control group B,with a significant difference(P<0.001);There was no significant difference in LVEF between control group A and control group B(P>0.05);The E/A in control group B was higher than that in control A,and the NT-proBNP in control group B was lower than that in control group A,and the difference was statistically significant(P<0.001).The total effective rate of treatment in the observation group was higher than that in control group A and control group B,and the total effective rate of treatment in control group B was higher than that in control group A,and the difference was statistically significant(P<0.05).Conclusion:Safflower yellower for injection combined with Xinhuosu has a significant effect in treatment of heart failure,it can increase LVEF and E/A,reduce NT-proBNP,which is worthy of clinical promotion.

关 键 词：红花黄色素 新活素 心力衰竭 左室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]