下颈椎椎弓根的显微形态学特征  

Micromorphological characteristics of the pedicle of the lower cervical vertebra

作　　者：李琨 张少杰 史君 王建 刘亚楠 朵岚 杨洋 郝韵腾 李志军 王星 Li Kun;Zhang Shaojie;Shi Jun;Wang Jian;Liu Yanan;Duo Lan;Yang Yang;Hao Yunteng;Li Zhijun;Wang Xing(Department of Anatomy,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Digital Medicine Center,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Physiology,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Graduate School,School of Basic Medicine,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学基础医学院解剖学教研室,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学基础医学院数字医学中心,内蒙古自治区呼和浩特市010110 [3]内蒙古医科大学基础医学院生理学教研室,内蒙古自治区呼和浩特市010110 [4]内蒙古医科大学基础医学院研究生学院,内蒙古自治区呼和浩特市010110

出　　处：《中国组织工程研究》2024年第12期1890-1894,共5页Chinese Journal of Tissue Engineering Research

基　　金：内蒙古自治区自然科学基金项目(2022QN03002),项目负责人:李琨;内蒙古医科大学青年基金项目(YKD2020QNCX055),项目负责人:李琨;内蒙古医科大学英才培育项目(YCPY2022019),项目负责人:李琨;内蒙古医科大学大学生创新创业项目(202110132025,202210132031,202210132011),项目负责人:李琨;国家自然科学基金资助项目(81860383),项目负责人:李志军;内蒙古自治区自然科学基金资助项目(2020LH08021),项目负责人:李志军;国家自然科学基金资助项目(81860382),项目负责人:王星;内蒙古自治区自然科学基金资助项目(2020MS03061),项目负责人:王星;内蒙古自治区高等学校青年科技英才支持计划资助项目(NJYT22009),项目负责人:王星;内蒙古自治区科技计划项目(2019GG158),项目负责人:王星;内蒙古医科大学科研重点项目(YKD2021ZD011),项目负责人:王星;内蒙古自治区卫生健康委医疗卫生科技计划项目(202201217),项目负责人:王星;内蒙古自治区自然科学基金资助项目(2019MS08017),项目负责人:张少杰。

摘　　要：背景:下颈椎椎弓根是脊柱后柱的主要应力部位,对人体重心稳定的维持及减轻振荡有重要意义,目前对其内部骨小梁特征、椎弓根与关节突及椎体的连接部位的特征研究鲜有报道,迫切需要了解椎弓根的精细解剖结构及其各部分关系和功能。目的:通过Micro-CT扫描下颈椎椎骨标本以观测椎弓根显微解剖学形态,测量和分析正常下颈椎椎弓根内骨小梁的微结构和形态计量学参数以评估颈椎的安全性能。方法:选取31套干燥成人下颈椎骨骼标本C3-C7进行Micro-CT扫描,通过对椎弓根内骨小梁感兴趣区的勾选与重建,观察下颈椎椎弓根内骨小梁的形态特征及走形方向,检测骨微细结构参数,并分析比较C3-C7椎弓根骨微细结构的差异性。结果与结论:①Micro-CT图像显示下颈椎椎弓根的蜂窝样骨小梁呈复杂的网状微结构,靠近皮质骨的骨小梁呈板层状,结构相对致密,并向前方椎体部和向后方关节突椎板部延伸;板状骨小梁向髓腔伸展转化为网状结构,再转化为杆状骨小梁,髓腔内杆状骨小梁分布稀疏;②骨小梁各形态参数统计结果显示,C4、C5椎弓根的骨小梁骨体积分数高于C7(P<0.05),C7椎弓根的骨表面积/骨体积高于C3、C4、C6(P<0.05),C7椎弓根的骨小梁骨表面密度高于C3、C4、C5、C6(P<0.05),C7椎弓根的骨小梁厚度高于C3、C4、C5(P<0.05),左侧椎弓根骨小梁的骨表面积/骨体积、骨表面密度比较大于右侧(P<0.05);③该文总结了C3-C7微结构变化规律,其中C7椎弓根的负荷能力及应力较差,该区发生损伤的风险较高。BACKGROUND:The lower cervical vertebral pedicle is the main stress site of the posterior column of the spine,which is of great significance for the maintenance of the stability of the human center of gravity and the reduction of shock.At present,there are few reports on the characteristics of the internal bone trabeculae,and the characteristics of the joint site of the vertebral pedicle with the articular process and the vertebral body.It is urgent to understand the fine anatomical structure of the vertebral pedicle and the relationship and function of each part.OBJECTIVE:To observe the microanatomical morphology of the vertebral pedicle by Micro-CT scanning of cervical vertebra specimens,and to measure and analyze the microstructure and morphometric parameters of the bone trabecula in the cervical pedicle under normal conditions to evaluate the safety performance of the cervical spine.METHODS:Micro-CT scanning was performed on 31 sets of cervical vertebrae C3-C7.By checking and reconstructing the areas of interest in the bone trabecular within the vertebral pedicle,the morphological characteristics and distribution direction of the bone trabecular within the cervical pedicle were observed,and the bone microstructure parameters were detected,and the differences in the bone microstructure of the C3-C7 vertebral pedicle were analyzed and compared.RESULTS AND CONCLUSION:(1)The Micro-CT images showed that the honeycomb bone trabeculae of the pedicle of the lower cervical spine presented a complex network of microstructures.The trabeculae near the cortical bone were lamellar and relatively compact,extending forward toward the vertebral body and backward toward the articular process lamina.Abatoid bone trabeculae extended into the medullary cavity and transformed into a network structure,and then into rod-shaped bone trabeculae.The rod-shaped bone trabeculae were sparsely distributed in the medullary cavity.(2)Statistical results of morphological parameters of bone trabeculae showed that bone volume fraction values in

关 键 词：脊柱 下颈椎 椎弓根 MICRO-CT 显微形态 骨小梁 

分 类 号：R445[医药卫生—影像医学与核医学] R322[医药卫生—诊断学] R-331[医药卫生—临床医学]