Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention  

作　　者：Luyao Feng Liqun Wang Yao Ma Wanglin Duan Sergio Martin-Saldana Ye Zhu Xianpeng Zhang Bin Zhu Chaowei Li Shibo Hu Mingjie Bao Ting Wang Yuan Zhu Fei Yang Yazhong Bu 

机构地区：[1]Institute of Medical Engineering,Department of Biophysics,School of Basic Medical Sciences,Health Science Center,Xi’an Jiaotong University,Xi’an,710061,China [2]Department of Reproductive Health,Jiangxi Maternal and Child Health Hospital,Nanchang,Jiangxi,330006,China [3]POLYMAT,Applied Chemistry Department,Faculty of Chemistry,University of the Basque Country UPV/EHU,Paseo Manuel de Lardizabal 3,20018,Donostia-San Sebastian,Spain [4]JXHC Key Laboratory of Fertility Preservation,Jiangxi Maternal and Child Health Hospital,Nanchang,Jiangxi,330006,China [5]School of Chemical Sciences,University of Chinese Academy of Sciences,Beijing,100049,China [6]Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Polymer Physics&Chemistry,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China

出　　处：《Bioactive Materials》2023年第9期82-97,共16页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(52103184,81660265,81960276);Natural Science Foundation of Jiangxi Province(20224BAB206026);Key Research and Development Program of Jiangxi Province(20202BBGL73065);Funding for Basic Scientific Research and‘Young Talent Support Plan’of Xi’an Jiaotong University(xzy012022038).

摘　　要：Intrauterine adhesion (IUA) is the fibrosis within the uterine cavity. It is the second most common cause of female infertility, significantly affecting women’s physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge for reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in IUA prevention. In this work, we prepare a series of self-healing hydrogels (P10G15, P10G20, and P10G25) with antioxidant and adhesive properties. Those hydrogels exhibit good self-healing properties and can adapt themselves to different structures. They possess good injectability and fit the shape of the human uterus. Moreover, the hydrogels exhibit good tissue adhesiveness, which is desirable for stable retention and therapeutic efficacy. The in vitro experiments using P10G20 show that the adhesive effectively scavenges ABTS+, DPPH, and hydroxyl radicals, rescuing cells from oxidative stress. In addition, P10G20 offers good hemocompatibility and in vitro and in vivo biocompatibility. Furthermore, P10G20 lowers down the in vivo oxidative stress and prevents IUA with less fibrotic tissue and better endometrial regeneration in the animal model. It can effectively downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). Altogether, these adhesives may be a good alternative for the clinical treatment of intrauterine adhesion.

关 键 词：ADHESIVE HYDROGEL Intrauterine adhesion SELF-HEALING ANTIOXIDANT 

分 类 号：TQ427.26[化学工程]