Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles:Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus  

作　　者：Qing-Song Deng Yuan Gao Bi-Yu Rui Xu-Ran Li Po-Lin Liu Zi-Yin Han Zhan-Ying Wei Chang-Ru Zhang Fei Wang Helen Dawes Tong-He Zhu Shi-Cong Tao Shang-Chun Guo 

机构地区：[1]Department of Orthopedic Surgery,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,600 Yishan Road,Shanghai,200233,China [2]School of Medicine,Shanghai Jiao Tong University,227 South Chongqing Road,Shanghai,200025,China [3]Institute of Microsurgery on Extremities,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,600 Yishan Road,Shanghai,200233,China [4]Department of Rheumatology,The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University,No.29,Xinglongxiang,Tianning District,Changzhou,213000,China [5]Shanghai Clinical Research Centre of Bone Diseases,Department of Osteoporosis and Bone Diseases,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,200233,China [6]Shanghai Key Laboratory of Orthopedic Implants,Department of Orthopedic Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.639 Zhizaoju Road,Shanghai,200011,China [7]Clinical and Translational Research Center for 3D Printing Technology,Medical 3D Printing Innovation Research Center,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200125,China [8]Department of Orthopedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,197 Ruijin Second Road,Shanghai,200025,China [9]Faculty of Health and Life Science,Oxford Brookes University,Headington Road,Oxford,OX30BP,UK [10]NIHR Oxford Health Biomedical Research Centre,Oxford,OX37JX,UK [11]College of Medicine and Health,St Lukes Campus,University of Exeter,Heavitree Road,Exeter,EX12LU,UK [12]School of Chemistry and Chemical Engineering,Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment,Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-Coding RNA,Institute for

出　　处：《Bioactive Materials》2023年第9期409-428,共20页生物活性材料（英文）

摘　　要：Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue necrosis.To solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to ROS.This F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)NPs.In addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound healing.Therefore,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration.

关 键 词：Mesoporous polydopamine nanoparticles(MPDA NPs) SS31 Photothermal antibacterial Mitochondrial function maintenance Diabetic wound healing 

分 类 号：R587.1[医药卫生—内分泌]