姜黄素-聚乙烯醇药物凝胶的制备及性能研究  

Preparation and properties of curcumin-polyvinyl alcohol drug hydrogel

作　　者：王培[1] 牛丽丽[1] 陈灵智[1] WANG Pei;NIU Lili;CHEN Lingzhi(Hengshui University,Department of Applied Chemistry,Hengshui 053000,China)

机构地区：[1]衡水学院应用化学系,河北衡水053000

出　　处：《中国塑料》2023年第7期34-40,共7页China Plastics

基　　金：衡水市教育科学研究“十四五”规划课题(2205251);河北省大学生创新创业训练计划项目(S202210101005);衡水学院2023年度校级课题(2023ZRZ05)。

摘　　要：以姜黄素为原药、聚乙烯醇为载体,制备了具有缓释性的姜黄素-聚乙烯醇药物凝胶。通过平衡溶胀度和红外对凝胶进行了表征;采用单因素和响应面法,考察了药物凝胶载药量的影响因素;通过标准曲线考察了药物凝胶的缓释性。结果表明,相同条件下,在40℃凝胶的溶胀度最大,为(171.53±0.21)%,红外表征表明该凝胶可进行后续实验;单因素法表明,姜黄素初始浓度为70μg/mL、时间为1.5 h和温度为40℃时,凝胶载药量达到最大为(43.43±0.243 2)mg/g;响应面法分析结果表明,姜黄素的初始浓度对载药量影响最显著,其次为温度,而吸附时间对载药量影响相对较小;在PBS缓冲液中,16 h内姜黄素累计释放率达到88.1%,释药行为接近一级方程,表明制得的药物凝胶具有一定的缓释作用。A type of controlled-release drug hydrogels was prepared with curcumin as an original drug and polyvinyl alcohol as a carrier.The structure and performance of the as-prepared drug hydrogels were characterized by using balanced swelling and Fourier-transform infrared spectroscopy.The effects of drug-loading of the hydrogels were investigated by using the single factor and response surface methods,and the controlled-release properties of the drug hydrogels were evaluated through a standard curve.The experimental results indicated that the hydrogels obtained a maximum swelling rate of(171.53±0.21) % at 40 oC under the same conditions.Based on the single-factor method,the drug-loading of the hydrogels reached a maximum of(43.43±0.243 2) mg/g at 40 oC for 1.5 h under the initial curcumin concentration of 70 μg/mL.The results from the response surface analysis indicated that the initial concentration of curcumin generated the most significant effect on the drug-loading,followed with temperature.However,the adsorption time only had a relatively small effect on the drug-loading.In the phosphate buffered solution,the cumulative release rate of curcumin reached 88.1 %,indicating a certain controlled-release effect of the drug hydrogels.

关 键 词：姜黄素 聚乙烯醇 凝胶 响应面 缓释 

分 类 号：TQ325.9[化学工程—合成树脂塑料工业]