L-半胱氨酸光学传感器研究与应用  

Research and application on developing colorimetric and fluorescent sensors for L-cysteine

作　　者：邓威森 肖国强 袁俊[1] 张慢乐 吴玲[1] 曹忠[1] Deng Wei-sen;Xiao Guo-qiang;Yuan Jun;Zhang Man-le;Wu Ling;Cao Zhong(Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation&Hunan Provincial Key Laboratory of Cytochemistry,School of Chemistry and Chemical Engineering,Changsha University of Science and Technology,Changsha 410114,China;Chongqing Academy of Metrology and Quality Inspection,Chongqing 401123,China)

机构地区：[1]长沙理工大学化学化工学院,电力与交通材料保护湖南省重点实验室,细胞化学湖南省重点实验室,长沙410114 [2]重庆市计量质量检测研究院,重庆401123

出　　处：《化学传感器》2022年第4期9-22,共14页Chemical Sensors

基　　金：国家自然科学基金(31527803);湖南省自然科学基金(2020JJ40559);湖南省教育厅科学研究项目(21A0182,21C0195);长沙理工大学大学生创新创业训练计划(No.2022-0165).

摘　　要：L-半胱氨酸(L-Cys)是含巯基的小分子氨基酸之一,在许多生理和病理过程中发挥关键作用,监测L-Cys水平对临床诊断和了解人体必要的生理过程至关重要。因此,开发准确、简单、快速的L-Cys检测方法受到研究者们的广泛关注。该文介绍了近年来光学传感器在检测L-Cys中的应用,着重介绍了不同种类纳米材料构建的L-Cys比色传感器与不同分子探针构建的L-Cys荧光传感器,并对比了不同比色传感器与不同荧光传感器的检测性能。L-cysteine(L-Cys)is one of the small sulfhydryl-containing amino acids that plays a key role in many physiological and pathological processes,which is essential on monitoring L-Cys levels for clinical diagnosis and understanding of physiological processes in the human body.Therefore,the development of accurate,simple,and rapid L-Cys assays has received a lot of attention from researchers.This paper introduces the application of optical sensors in the detection of L-Cys in recent years,focusing on L-Cys colorimetric sensors constructed by different kinds of nanomaterials and L-Cys fluorescent sensors constructed by different molecular probes,and comparison with the detection performance of different colorimetric sensors and different fluorescent sensors.

关 键 词：L-半胱氨酸 比色传感器 荧光传感器 纳米材料 分子探针 应用 

分 类 号：TP212.14[自动化与计算机技术—检测技术与自动化装置] O629.7[自动化与计算机技术—控制科学与工程]