miR-155、PDCD4、GSN在高血压性脑出血中的表达及预后价值研究  

Expression and prognostic predictive value of miR-155,PDCD4 and GSN in hypertensive cerebral hemorrhage

作　　者：裴献光[1] 魏海亮[1] 高芳 许亚宁 王志强[1] PEI Xianguang;WEI Hailiang;GAO Fang;XU Yaning;WANG Zhiqiang(the First Department of Neurosurgery,the First Hospital of Handan City,Handan,Hebei 056002,China;the Third Department of Surgery,the First Hospital of Handan City,Handan,Hebei 056002,China)

机构地区：[1]邯郸市第一医院神外一科,河北邯郸056002 [2]邯郸市第一医院外三科,河北邯郸056002

出　　处：《国际检验医学杂志》2023年第14期1670-1675,共6页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题(20200186)。

摘　　要：目的探讨微小核糖核酸(miRNA)-155(miR-155)、程序性细胞死亡蛋白4(PDCD4)、凝溶胶蛋白(GSN)在高血压性脑出血(HICH)中的表达及在预后判断中的价值。方法将2021年1月至2022年1月该院收治的150例HICH患者纳入研究作为研究组。另外,将同期150例无脑出血的高血压患者纳入研究作为对照组。比较研究组、对照组及不同严重程度、不同预后患者miR-155、PDCD4、GSN水平及一般资料。分析各指标与疾病严重程度、预后的相关性。分析HICH预后不良的独立危险因素及各指标单独及联合检测在预后判断中价值。结果研究组miR-155和PDCD4水平均高于对照组,而GSN水平低于对照组(P<0.05)。随HICH严重程度加重,miR-155、PDCD4水平增高,GSN水平降低(P<0.05)。预后不良组miR-155和PDCD4水平均高于预后良好组(P<0.05),而GSN水平低于预后良好组(P<0.05)。miR-155、PDCD4与HICH严重程度呈正相关(r=0.653、0.642,P<0.05),与HICH预后呈负相关(r=-0.625、-0.575,P<0.05);GSN与HICH严重程度呈负相关(r=-0.591,P<0.05),与HICH预后呈正相关(r=0.583,P<0.05)。预后不良组出血量≥60 mL占比高于预后良好组(P<0.05)。miR-155、PDCD4水平升高,GSN水平降低是HICH患者预后不良的危险因素(P<0.05)。miR-155、PDCD4、GSN联合检测用于HICH患者预后不良预测的曲线下面积为0.954,高于miR-155、PDCD4、GSN单独检测(P<0.05)。结论miR-155、PDCD4在HICH患者中呈高表达,GSN呈低表达。miR-155、PDCD4水平升高,GSN水平降低是HICH患者预后不良的危险因素。3项联合检测用于HICH患者预后判断中的价值较高。Objective To investigate the expression and prognostic predictive value of microRNA(miRNA)-155(miR-155),programmed cell death protein 4(PDCD4),and gelsolin(GSN)in hypertensive cerebral hemorrhage(HICH).Methods A total of 150 patients with HICH admitted to the hospital from January 2021 to January 2022 were enrolled in the study as the study group.In addition,150 hypertensive patients without cerebral hemorrhage treated in the hospital during the same period were enrolled as the control group.The levels of miR-155,PDCD4,GSN and general data were compared between the study group and the control group,and patients with different severity and different prognosis.The correlations between the indicators and the severity and prognosis of HICH were analyzed.The independent risk factors of poor prognosis of HICH and the value of each indicator and their combination in prognosis were analyzed.Results The levels of miR-155 and PDCD4 in the study group were higher than those in the control group,while the level of GSN was lower than that in the control group(P<0.05).As the severity of HICH increased,the levels of miR-155 and PDCD4 increased,and the level of GSN decreased(P<0.05).The levels of miR-155 and PDCD4 in the poor prognosis group were higher than those in the good prognosis group(P<0.05),while the level of GSN was lower than that in the good prognosis group(P<0.05).miR-155 and PDCD4 were positively correlated with the severity of HICH(r=0.653,0.642,P<0.05),and negatively correlated with the prognosis of HICH(r=-0.625,-0.575,P<0.05).GSN was negatively correlated with the severity of HICH(r=-0.591,P<0.05),and positively correlated with the prognosis of HICH(r=0.583,P<0.05).The poor prognosis group had a significantly higher proportion of patients with blood loss≥60 mL than the good prognosis group(P<0.05).The increased levels of miR-155 and PDCD4 and the decreased level of GSN were risk factors for poor prognosis in HICH patients(P<0.05).The area under the curve of combined detection of miR-155,PDCD4,and GSN for pred

关 键 词：高血压性脑出血 微小核糖核酸-155 程序性细胞死亡蛋白4 凝溶胶蛋白 

分 类 号：R446.11[医药卫生—诊断学]