海绵共附生真菌Aspergillus giganteus MA 46-5吲哚喹唑啉类生物碱成分  

The indole quinazoline alkaloids from the sponge-associated fungus Aspergillus giganteus MA 46-5

作　　者：周逢国 蒋伟欣 卢欢 陈乐怡 林昕历 何璐萍 何细新[1] 张翠仙[1] ZHOU Fengguo;JIANG Weixin;LU Huan;CHEN Leyi;LIN Xinli;HE Luping;HE Xixin;ZHANG Cuixian(School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中山大学学报（自然科学版）（中英文）》2023年第4期83-92,共10页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省自然资源厅海洋经济发展(海洋六大产业)专项(GDNRC[2021]048,GDNRC[2020]039);国家自然科学基金(82273845,81741160);广东省大学生创新创业项目(S202010572122);广东省科技创新战略专项(pdjh2023b0126)。

摘　　要：对1株富产吲哚喹唑啉类生物碱(IQAs)的海绵共附生真菌Aspergillus giganteus MA 46-5的IQAs类成分进行了研究。根据IQAs的结构特征,在TLC、LC-MS和GNPS(global natural products social molecular networking)技术的共同指导下,从大米培养基的乙酸乙酯部位分离得到10个IQAs类生物碱。通过NMR、HR-ESI-MS、OR和CD等方法并结合文献比对鉴定其分别为:tryptoquivaline(1)、nortryptoquivaline(2)、deoxytryptoquivaline(3)、deoxynortryptoquivaline(4)、aspertoryadin C(5)、aspertoryadin G(6)、quinadoline A(7)、fiscalin E (8)、quinadoline B(9)和prelapatin B(10)。8和10为首次从Aspergillus属中得到,2、4~7为首次从Aspergillus giganteus中分离得到。According to the structure feature of indole quinazoline alkaloids(IQAs),under the guidance of TLC,LC-MS and GNPS(global natural products social molecular networking),IQAs from sponge-associated fungus Aspergillus giganteus MA 46-5 were studied and ten IQAs were isolated from rice medium of MA 46-5.Based on NMR,HR-ESI-MS,OR,CD and comparison with the literature,their structures were determined as tryptoquivaline(1),nortryptoquivaline(2),deoxytryptoquivaline(3),deoxynortryptoquivaline(4),aspertoryadin C(5),aspertoryadin G(6),quinadoline A(7),fiscalin E(8),quinadoline B(9) and prelapatin B(10).8 and 10 were isolated from Aspergillus for the first time,and 2,4-7 were firstly obtained from Aspergillus giganteus.

关 键 词：海绵共附生真菌 Aspergillus giganteus MA 46-5 吲哚喹唑啉类生物碱 

分 类 号：R931.77[医药卫生—生药学] O629.3[医药卫生—药学]