越鞠温胆汤加减联合穴位贴敷治疗肝胃郁热型胆汁反流性胃炎临床研究  

Clinical Study on Treatment of Liver and Stomach Stagnation Type Bile Reflux Gastritis by Modified Yueju Wendan Decoction and Acupoint Application

作　　者：刘海涛 李奇素 呼菁玉 牛登锋 刘争辉 LIU Haitao;LI Qisu;HU Jingyu;NIU Dengfeng;LIU Zhenghui(Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;Shaanxi University of Chinese Medicine,Shaanxi Xixian New Area 712046,China;Yan an Chinese Medicine Hospital,Shaanxi Yan an 716009,China)

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712000 [2]陕西中医药大学,陕西咸阳712046 [3]延安市中医医院,陕西延安716099

出　　处：《现代中医药》2023年第4期60-64,共5页Modern Chinese Medicine

基　　金：陕西省中医药管理局课题(2021-GJ-JG009);陕西中医药大学科研基金项目(2020GP40);陕西中医药大学附属医院科研基金项目(2020MS005)。

摘　　要：目的观察越鞠温胆汤加减联合穴位贴敷治疗肝胃郁热型胆汁反流性胃炎的临床疗效。方法按随机数字表法将93例胆汁反流性胃炎(肝胃郁热型)患者随机分为治疗组47与对照组各46例,治疗组采用越鞠温胆汤加减联合穴位贴敷治疗,对照组予以马来酸曲美布汀、雷贝拉唑肠溶胶囊、铝镁二甲硅油咀嚼片治疗;疗程均为8 w,观察两组治疗前后的临床疗效、症状积分、内镜下胃黏膜变化及不良反应,综合评价疗效。结果治疗组总有效率(93.61%)显著高于对照组(82.60%),两组比较差异有统计学意义(P<0.05)。两组治疗后症状均明显好转,临床症状积分较治疗前比较,差异有统计学意义(P<0.01),治疗组治疗后各临床症状积分与对照组比较,差异有统计学意义(P<0.05)。治疗组在改善反流、腺体萎缩方面,作用优于对照组(P<0.05),在改善黏膜充血水肿、糜烂、肠化方面疗效无统计学差异(P>0.05)。结论越鞠温胆汤加减联合穴位贴敷治疗胆汁反流性胃炎疗效显著,值得临床推广。Objective To observe the clinical efficacy of modified Yueju Wendan decoction combined with acupoint application in the treatment of bile reflux gastritis of liver stomach stagnation heat type.Methods According to the method of random number table,93 patients with bile reflux gastritis(liver stomach heat stagnation type)were randomly divided into the treatment group(47 cases)and the control group(46 cases).The treatment group was treated with Yueju Wendan decoction plus acupoint application,and the control group was treated with trimebutine maleate,rabeprazole enteric coated capsules,and aluminum magnesium dimethicone oil chewable tablets;The course of treatment was 8 weeks.The clinical efficacy,symptom score,endoscopic changes of gastric mucosa and adverse reactions were observed before and after treatment in both groups,and the efficacy was comprehensively evaluated.Results The total effective rate of the treatment group(93.61%)was significantly higher than that of the control group(82.60%),and the difference between the two groups was statistically significant(P<0.05).After treatment,the symptoms of both groups improved significantly,and the clinical symptom scores showed a statistically significant difference compared to before treatment(P<0.01).After treatment,the clinical symptom scores of the treatment group showed a statistically significant difference compared to the control group(P<0.05).The treatment group had a better effect than the control group in improving reflux and glandular atrophy(P<0.05),and there was no statistically significant difference in improving mucosal congestion,edema,erosion,and intestinal metaplasia(P>0.05).Conclusion The combination of modified Yueju Wendan decoction and acupoint application has a significant therapeutic effect on bile reflux gastritis,which is worthy of clinical promotion.

关 键 词：胆汁反流性胃炎 肝胃郁热 越鞠温胆汤 穴位贴敷 

分 类 号：R244.9[医药卫生—针灸推拿学]