撤机对离心血泵血液相容性影响的数值研究  

Numerical study of blood pump weaning effects on hemocompatibility of centrifugal blood pump

作　　者：谢楠 唐雨萌[1,2] 张岩 柳阳威[1,2] XIE Nan;TANG Yumeng;ZHANG Yan;LIU Yangwei(School of Energy and Power Engineering,Beihang University,Beijing 100191,China;National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics,Beihang University,Beijing 100191,China;Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China)

机构地区：[1]北京航空航天大学能源与动力工程学院,北京100191 [2]北京航空航天大学航空发动机气动热力国家级重点实验室,北京100191 [3]中国医学科学院阜外医院,北京100037

出　　处：《北京航空航天大学学报》2023年第7期1680-1688,共9页Journal of Beijing University of Aeronautics and Astronautics

基　　金：国家自然科学基金(51976006,52106039);航空科学基金(2018ZB51013)。

摘　　要：采用非定常数值模拟方法系统评估某离心血泵原型与改型在4个撤机阶段的血流动力学特性和血液相容性。对速度、湍动能、叶表压力的分布规律及不同撤机阶段的血液损伤进行研究,并对各监测点的压力脉动进行分析。研究结果表明:在降低心脏泵流量和供压的第1阶段(撤机阶段Ⅰ),原型和改型均有较好的血液相容性,满足抗溶血和抗血栓的性能要求,间隙泄漏涡是造成溶血主要的流动特征;随着撤机的进行,间隙泄漏涡强度明显减弱,溶血值呈显著的下降趋势,其脉动幅度也大大降低,改型的溶血值比原型减少30%以上;各监测点压力频谱呈现典型的离散特征,相较于原型,改型的转静干涉作用更加强烈,对血泵的电磁控制技术提出更高的要求。The four stages of blood pump weaning are used to methodically assess the hemodynamic performance and hemocompatibility of the datum and modified centrifugal blood pumps.The distribution of parameters and the changes of normalized index of hemolysis in four stages of weaning are researched,the pressure pulsation of each monitoring point is also analyzed.Results show that both the datum pump and the modified pump own good hemocompatibility,and it satisfies the requirement of anti-hemolysis and anti-thrombosis in the first blood pump weaning stage.The leakage vortex formed in clearance is the main flow characteristic that induces hemolysis.The intensity of leakage vortex becomes weaken,and the index of hemolysis as well as its pulsation decrease significantly during the blood pump weaning process.Compared with the datum pump,the NIH of the modified pump is reduced by more than 30%.The pressure spectrum exhibits typical discrete characteristics,and the modified pump's rotor-stator interaction is stronger than that of the datum pump,indicating a high need for the blood pump's electromagnetic control technology.

关 键 词：离心血泵 撤机 血液相容性 溶血 数值模拟 

分 类 号：V239[航空宇航科学与技术—航空宇航推进理论与工程] R318[医药卫生—生物医学工程]