硼中子俘获疗法的原理及临床应用  

Principles and Clinical Applications of Boron Neutron Capture Therapy

作　　者：刘志凯 程炜诗 吴王锁[2] 梁天骄[3] 邢庆子[4] 张紫竹 刘志博 刘渊豪 潘建基[8] 朱晒红[9] 李晴暖[10] 张福泉[1] 邱杰 霍力[11] LIU Zhikai;CHENG Weishi;WU Wangsuo;LIANG Tianjiao;XING Qingzi;ZHANG Zizhu;LIU Zhibo;LIU Yuanhao;PAN Jianji;ZHU Shaihong;LI Qingnuan;ZHANG Fuquan;QIU Jie;HUO Li(Department of Radiotherapy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;School of Nuclear Science and Technology,Lanzhou University,Lanzhou 730000,China;Institute of High Energy Physics,Chinese Academy of Sciences,Dongguan,Guangdong 100049,China;Department of Engineering Physics,Tsinghua University,Beijing 100084,China;Beijing Nuclear Industry Hospital,Beijing 100045,China;School of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;China Boron(Xiamen)Medical Devices Co.,Ltd.,Xiamen,Fujian 361028,China;Fujian Medical University,Fuzhou 350122,China;The Third Xiangya Hospital of Central South University,Changsha 410013,China;Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院放射治疗科,北京100730 [2]兰州大学核科学与技术学院,兰州730000 [3]中国科学院高能物理研究所,广东东莞100049 [4]清华大学工程物理系,北京100084 [5]北京核工业医院,北京100045 [6]北京大学化学与分子工程学院,北京100871 [7]中硼(厦门)医疗器械有限公司,福建厦门361028 [8]福建医科大学,福州350122 [9]中南大学湘雅三医院,长沙410013 [10]中国科学院上海应用物理研究所,上海201800 [11]中国医学科学院北京协和医院核医学科,北京100730

出　　处：《协和医学杂志》2023年第4期698-705,共8页Medical Journal of Peking Union Medical College Hospital

摘　　要：硼中子俘获疗法(Boron neutron capture therapy,BNCT)是一项处于快速发展中的先进放疗技术。该技术通过在癌细胞内发生的10B(n,α)7Li原子核反应杀死癌细胞,是一种原子级别的二元靶向治疗,其临床实施需要专业技术与装置支持。BNCT的核心要素包括适宜的中子源及中子俘获药物。相较于传统放疗技术,BNCT在治疗局部复发肿瘤(如中枢神经系统肿瘤和头颈部肿瘤)中优势突出,能够更好地保护正常器官,特别是对于已经对周围器官产生明显侵犯的肿瘤具有良好的应用前景。本文主要阐述BNCT的技术原理、核心要素及其临床应用,以期为临床诊疗提供参考。Boron neutron capture therapy(BNCT)is an advanced radiation therapy technique that is rapidly developing in the field of cancer treatment.This technique,an atomic⁃level binary targeted therapy,kills cancer cells by causing a 10B(n,α)7Li nuclear reaction within the cancer cells,and its clinical imple⁃mentation requires professional technology and device support.The core elements of BNCT include appropriate neutron sources and neutron capture drugs.Compared with traditional radiotherapy techniques,BNCT shows outstanding advantages in treating locally recurrent tumors,such as central nervous system tumors and head and neck tumors.Furthermore,it can better protect normal organs,especially for tumors that have already signifi⁃cantly invaded surrounding organs,demonstrating its promising future prospects.This article mainly elaborates on the technical principles,core elements,and clinical applications of BNCT,in hope of providing reference for clinical diagnosis and treatment.

关 键 词：硼中子俘获疗法 中子源 硼携带剂 放射治疗 恶性肿瘤 

分 类 号：R45[医药卫生—治疗学] R73[医药卫生—临床医学]