幽门螺杆菌感染与非酒精性脂肪性肝病的相关性及潜在机制  

Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non⁃alcoholic Fatty Liver Disease

作　　者：陈丹妮 王世令 路红[2,3] 郑亚 王玉平[2,4] 任茜[2,3,4] CHEN Danni;WANG Shiling;LU Hong;ZHENG Ya;WANG Yuping;REN Qian(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,China;Digestive Endoscope Center,The First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Key Laboratory of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院消化科,兰州730000 [3]兰州大学第一医院消化内镜中心,兰州730000 [4]兰州大学第一医院甘肃省胃肠病重点实验室,兰州730000

出　　处：《协和医学杂志》2023年第4期833-838,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：甘肃省自然科学基金(21JR7RA381);甘肃省卫生行业科研计划项目(GSWSKY2020-07);兰州大学中央高校基本科研业务费(lzujbky-2021-ct17);兰州大学第一医院院内基金(ldyyyn2019-74)。

摘　　要：随着人们生活方式的改变,非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)目前已成为世界范围内最常见的肝脏疾病,并可能发展为肝硬化、肝细胞癌(hepatocellular carcinoma,HCC),严重威胁人类健康。目前NAFLD的治疗仍以调整生活方式、控制血糖及血脂等危险因素为主,尚无有效治疗药物,因此,对于NAFLD发病机制的研究具有重要意义。近年来的研究表明,幽门螺杆菌(Helicobacter pylori,HP)感染可能通过诱发IR、改变脂质谱、促进氧化应激、改变肠道通透性和调控基因表达导致NAFLD的发生。本文就HP感染与NAFLD之间的相关性及潜在机制相关研究进展作一综述,以期为NAFLD的诊治提供新思路。Since people􀆳s lifestyles have changed,non⁃alcoholic fatty liver disease(NAFLD)has emerged as the most prevalent liver condition globally.It can progress to cirrhosis and hepatocellular carcinoma(HCC),both of which pose major risks to people􀆳s health.Currently,the treatment of NAFLD is still based on lifestyle modification,glycemic and lipid control,and other risk factors,and there are no effective therapeutic drugs.Therefore,it is important to study the pathogenesis of NAFLD.Recent studies have shown that Helico⁃bacter pylori(HP)infection is associated with the development of NAFLD,and HP infection may contribute to the development of NAFLD by inducing insulin resistance,altering the lipid profile,promoting oxidative stress,changing intestinal permeability,and regulating gene expression.Therefore,this paper reviews the correlation between HP infection and NAFLD and the potential pathogenesis of NAFLD due to HP infection,with the aim of providing new ideas for the diagnosis and treatment of NAFLD.

关 键 词：幽门螺杆菌 非酒精性脂肪性肝病 胰岛素抵抗 肠道菌群 

分 类 号：R575[医药卫生—消化系统] R-1[医药卫生—内科学]