“消肿散”剂型优化的复方芙蓉叶凝胶治疗膝关节滑膜炎  

Compound cottonrose hibiscus leaf gel plaster of optimal “Xiaozhongsan” formulation for knee synovitis

作　　者：颜威 孔博[2] 奚小冰[1,3,4] 许勇 贾友冀 阮贝特[1,4] 张家慧 马泓泓 李中伟 Yan Wei;Kong Bo;Xi Xiaobing;Xu Yong;Jia Youji;Ruan Beite;Zhang Jiahui;Ma Honghong;Li Zhongwei(Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Wuxi Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Wuxi 214100,Jiangsu Province,China;Shanghai Key Laboratory of Prevention and Treatment of Bone and Joint Diseases,Shanghai 200025,China;Shanghai Institute of Traumatology and Orthopedics,Shanghai 200025,China Yan Wei,Master,Physician,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Corresponding author:Li Zhongwei,Chief physician,Shanghai Institute of Traumatology and Orthopedics,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市200025 [2]上海交通大学医学院附属瑞金医院无锡分院,江苏省无锡市214100 [3]上海市中西医结合防治骨与关节病损重点实验室,上海市200025 [4]上海市伤骨科研究所,上海市200025

出　　处：《中国组织工程研究》2024年第10期1580-1585,共6页Chinese Journal of Tissue Engineering Research

基　　金：上海市卫生和计划生育委员会中医药科研课题(2018LP025),项目负责人:李中伟;上海市进一步加快中医药传承创新发展三年行动计划项目(2021-2023年)[ZY(2021-2023)-0208],项目负责人:奚小冰;上海市进一步加快中医药传承创新发展三年行动计划项目(2021-2023年)[ZY(2021-2023)-0209-03],项目负责人:奚小冰;上海市青年科技英才扬帆计划项目(20YF1427400),项目负责人:颜威;上海市临床重点专科建设项目(SHSLCZDZK04802),项目负责人:奚小冰;上海交通大学“交大之星”计划医工交叉重点项目(YG2019ZDA16),项目负责人:奚小冰;上海市中西医结合旗舰医院建设项目[ZY(2021-2023)-0205-01],项目参与者:奚小冰、颜威;海派中医流派传承创新团队建设项目(2021LPTD-003),项目负责人:奚小冰。

摘　　要：背景:前期研究证实,新型复方芙蓉叶凝胶膏剂治疗急性软组织肿胀具有良好的效果。目的:观察复方芙蓉叶凝胶膏剂治疗膝关节滑膜炎的临床疗效。方法:选择2019年12月至2021年5月上海交通大学医学院附属瑞金医院诊治的膝关节滑膜炎患者72例,采用随机数字表法分为试验组与对照组,每组36例。试验组患者病患处进行复方芙蓉叶凝胶膏剂贴敷治疗,1次/d,12 h/次;对照组患者病患处进行双氯芬酸二乙胺乳胶剂涂抹治疗,2次/d。治疗28 d后,对比两组患者目测类比评分、WOMAC骨关节炎指数评分、SF-36生活质量评分、膝关节滑膜厚度及综合疗效。结果与结论:①两组患者治疗后的目测类比评分均低于治疗前(P<0.05),试验组患者治疗7,14,28 d后的目测类比评分均低于对照组(P<0.05);②两组患者治疗后的WOMAC骨关节炎指数评分均低于治疗前(P<0.05),试验组患者治疗7,14,28 d后的WOMAC骨关节炎指数评分均低于对照组(P<0.05);③两组患者治疗28 d后的SF-36生活质量评分均高于治疗前(P<0.05),试验组治疗28 d后的SF-36生活质量评分高于对照组(P<0.05);④试验组治疗28 d后的膝关节滑膜厚度小于对照组(P<0.05),治疗有效率高于对照组(P<0.05);⑤结果表明,与采用双氯芬酸二乙胺乳胶剂相比,新型复方芙蓉叶凝胶膏剂可以更好地缓解膝关节疼痛、改善膝关节功能、减少滑膜增生、提高患者整体生活质量。BACKGROUND:Previous studies have confirmed that the new compound cottonrose hibiscus leaf gel plaster has a good effect in the treatment of acute soft tissue swelling.OBJECTIVE:To observe the clinical efficacy of compound cottonrose hibiscus leaf gel plaster in the treatment of synovitis of the knee joint.METHODS:Seventy-two patients with knee synovitis were selected from Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from December 2019 to May 2021.These patients were randomly divided into a trial group and a control group,with 36 cases in each group.The trial group was treated with compound cottonrose hibiscus leaf gel plaster,once a day,12 hours each time,while the control group was treated with Diclofenac Diethylamine Emulgel,twice a day.After 28 days of treatment,visual analog scale score,WOMAC Osteoarthritis Index score,quality of life score(SF-36),thickness of knee synovium and comprehensive curative effect were compared between the two groups.RESULTS AND CONCLUSION:(1)Visual analog scale scores after treatment were lower than those before treatment(P<0.05).Visual analog scale scores in the trial group after 7,14 and 28 days of treatment were lower than those in the control group(P<0.05).The WOMAC Osteoarthritis Index scores of the two groups after treatment were lower than those before treatment(P<0.05),and the WOMAC Osteoarthritis Index scores in the trial group after 7,14 and 28 days of treatment were lower than those in the control group(P<0.05).(3)The SF-36 quality of life score in the two groups after 28 days of treatment was higher than that before treatment(P<0.05).SF-36 quality of life score in the trial group after 28 days of treatment was higher than that in the control group(P<0.05).(4)After 28 days of treatment,the thickness of knee synovium in the trial group was less than that in the control group(P<0.05),and the effective rate in the trial group was higher than that in the control group(P<0.05).(5)These findings indicate that compared with Diclofenac Diethylam

关 键 词：膝关节滑膜炎 膝关节骨关节炎 复方芙蓉叶凝胶膏剂 外治 膏药 药物治疗 

分 类 号：R453[医药卫生—治疗学] R316[医药卫生—临床医学] R289