千金苇茎汤对慢性阻塞性肺疾病急性加重期患者肺功能及嗜酸性粒细胞的影响  

Effects of Qianjin Weijing Decoction on Lung Function and Eosinophils in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：李凡 童波[2] 唐斌[2] 肖组克[2] 付云 LI Fan;TONG Bo;TANG Bin;XIAO Zu-ke;FU Yun(Department of Respiratory Medicine,Nanchang Third Hospital,Nanchang 330009,China;Department of Respiratory and Critical Care Medicine,Jiangxi Provincial People’s Hospital,Nanchang 330006,China;Department of General Practice,Jiangxi Provincial People’s Hospital,Nanchang 330006,China)

机构地区：[1]南昌市第三医院呼吸内科,南昌330009 [2]江西省人民医院呼吸与危重症医学科,南昌330006 [3]江西省人民医院全科医学科,南昌330006

出　　处：《实用临床医学（江西）》2023年第3期1-4,共4页Practical Clinical Medicine

基　　金：江西省卫生计生委中医药科研计划(2018A098)。

摘　　要：目的观察千金苇茎汤对嗜酸性粒细胞型慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能及嗜酸性粒细胞的影响.方法将60例AECOPD患者按随机数字表法分为对照组和干预组,每组30例.对照组给予常规治疗,干预组在常规治疗基础上给予千金苇茎汤治疗.比较2组治疗前后肺功能指标[第1秒用力呼气容积占预计值百分比(FEV1%prep)、FEV1/用力肺活量(FVC)比值(FEV1/FVC)]及外周血嗜酸性粒细胞(EOS)比值、诱导痰嗜酸性粒细胞阳离子蛋白(ECP)水平的改善情况.结果干预组临床症状缓解时间较对照组显著缩短(P<0.05).2组治疗后FEV1%prep、FEV1/FVC值均较治疗前显著升高,且干预组治疗后FEV1/FVC值显著高于对照组,差异均有统计学意义(P<0.05).对照组治疗前后EOS比值、ECP水平比较差异无统计学意义(P>0.05);干预组治疗后EOS比值、ECP水平均较治疗前显著降低,且显著低于对照组治疗后,差异均有统计学意义(P<0.05).结论千金苇茎汤可通过降低AECOPD患者外周血EOS比值及诱导痰ECP表达,改善AECOPD患者肺功能,缩短AECOPD患者临床症状缓解时间.Objective To evaluate the effect of Qianjin Weijing decoction on lung function and eosinophils in patients with eosinophilic acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Sixty patients with AECOPD were randomly given conventional treatment alone(control group,30 patients)or in combination with Qianjin Weijing decoction(intervention group,30 patients).The forced expiratory volume in one second to predicted value(FEV1%prep),forced expiratory volume in one second to forced vital capacity(FEV1/FVC)ratio,peripheral blood eosinophil(EOS)ratio,and induced sputum eosinophil cationic protein(ECP)level were compared between the two groups.Results The time to clinical remission in the intervention group was shorter than that in the control group(P<0.05).After treatment,the FEV1%prep and FEV1/FVC ratio increased in both groups,and FEV1/FVC ratio in the intervention group was higher than that in the control group(P<0.05).No obvious changes in EOS ratio and ECP level after treatment in the control group(P>0.05).However,after treatment,both EOS ratio and ECP level decreased in the intervention group,and those in the intervention group were lower than those in the control group(P<0.05).Conclusion Qianjin Weijing decoction can improve lung function and shorten the time to clinical symptom remission in AECOPD patients through reducing peripheral blood EOS ratio and induced sputum ECP expression.

关 键 词：慢性阻塞性肺疾病急性加重期 肺功能 千金苇茎汤 嗜酸性粒细胞 嗜酸性粒细胞阳离子蛋白 

分 类 号：R563.3[医药卫生—呼吸系统]