细胞自噬在PD相关并发症中作用的研究进展  

Research progress on the role of autophagy in PD-related complications

作　　者：杨嘉洁 姚翠微 YANG Jiajie;YAO Cuiwei(Institute of Kidney Disease,Affiliated Hospital of Guangdong Medical University,Zhanjiang Guangdong 524001)

机构地区：[1]广东医科大学附属医院肾脏疾病研究所,广东湛江524001

出　　处：《当代医药论丛》2023年第14期103-107,共5页

基　　金：静脉激素强化治疗加口服激素与单纯口服激素对治疗高度水肿微小病变型肾病综合征患者的随机对照研究,项目编号:2021A05083。

摘　　要：腹膜透析(PD)是一种重要的肾脏替代疗法。近年来,进行PD的人数逐年增加。但长期行PD会引起相关并发症,造成腹膜功能障碍,最终导致患者转为血液透析。自噬是维持细胞和生物体内环境稳定的核心分子通路。细胞自噬在PD相关并发症中的作用目前尚未完全明确。本文系统性回顾了近年来细胞自噬在PD相关并发症中的相关研究,为防治PD相关并发症提供潜在的新靶点。Peritoneal dialysis(PD)is an important renal replacement therapy.In recent years,the number of people with PD has increased year by year.However,long-term PD will cause related complications,resulting in peritoneal dysfunction,and eventually lead to patients to hemodialysis.Autophagy is a core molecular pathway that maintains the stability of the environment in cells and organisms.The role of autophagy in PD-related complications has not been fully defined.This review systematically reviewed the recent studies on autophagy in PD-related complications,providing potential new targets for prevention and treatment of PD-related complications.

关 键 词：腹膜透析 腹膜炎 腹膜纤维化 细胞自噬 

分 类 号：R459.5[医药卫生—治疗学]