腹腔灌注化疗联合加热治疗对于中晚期消化道肿瘤的有效性及安全性分析  

Efficacy and Safety of Intraperitoneal Infusion Chemotherapy Combined with Heating Therapy for Middle to Advanced Gastrointestinal Tumors

作　　者：王殿栋[1] 辛佳音[2] WANG Diandong;XIN Jiayin(Department of Intervention,Second Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia Autonomous Region,014000 China;Department of Geriatrics,First Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia Autonomous Region,014000 China)

机构地区：[1]包头市包头医学院第二附属医院介入科,内蒙古包头014000 [2]包头市包头医学院第一附属医院老年科,内蒙古包头014000

出　　处：《系统医学》2023年第7期180-184,共5页Systems Medicine

摘　　要：目的探究中晚期消化道肿瘤患者开展腹腔灌注化疗联合加热治疗的临床效果及安全性。方法选取2018年1月—2020年12月包头市包头医学院第二附属医院收治的92例中晚期消化道肿瘤患者,通过抽签的方式随机分为对照组和观察组,各46例。对照组患者给予单纯腹腔灌注化疗干预,观察组在腹腔灌注化疗基础上进行加热治疗。对比两组临床疗效、不良反应发生率,治疗前后肿瘤标志物、免疫功能指标。结果观察组总有效率为86.69%高于对照组的67.39%,差异有统计学意义(P<0.05)。治疗后,观察组患者的肿瘤标志物水平比对照组更低,差异有统计学意义(P<0.05)。治疗后,观察组患者的免疫功能指标比对照组更高,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论中晚期消化道肿瘤患者联合开展腹腔灌注化疗与加热治疗能够有效提升临床疗效,对患者的免疫功能有良好的改善作用。Objective To investigate the clinical effect and safety of peritoneal perfusion chemotherapy combined with heating therapy in patients with intermediate and advanced gastrointestinal tumors.Methods A total of 92 patients with advanced gastrointestinal tumors admitted to the Second Affiliated Hospital of Baotou Medical College in Baotou City from January 2018 to December 2020 were selected and randomly divided into control group and observation group by drawing lots,with 46 cases each.Patients in the control group were treated with intraperitoneal perfusion chemotherapy alone,and the observation group underwent heat therapy on the basis of peritoneal perfusion chemotherapy.The clinical efficacy,incidence of adverse reactions,tumor markers and immune function indexes before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 86.69%,which was higher than that of the control group(67.39%),and the difference was statistically significant(P<0.05).After treatment,the level of tumor markers in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the immune function indexes of patients in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions between the two groups were compared,and the difference was not statistically significant(P>0.05).Conclusion The combination of peritoneal perfusion chemotherapy and heating therapy in patients with intermediate and advanced gastrointestinal tumors can effectively improve the clinical efficacy and improve the immune function of patients.

关 键 词：腹腔灌注化疗 加热治疗 中晚期消化道肿瘤 免疫功能 不良反应 

分 类 号：R59[医药卫生—内科学]