乙型肝炎病毒共价闭合环状DNA清除的研究进展  

Progress in the Study of Covalently Closed Circular DNA Clearance of Hepatitis B Virus

作　　者：李成 莫雪 牛文霞 李明明 付丽娟 LI Cheng;MO Xue;NIU Wenxia;LI Mingming;FU Lijuan(Xiaogan Central Hospital,Xiaogan,Hubei Province,432000 China;Department of Infection,Xiang'an Hospital Affiliated to Xiamen University,Xiamen,Fujian Province,361000 China;Xiamen Quality Control Center for Infectious Diseases,Xiamen,Fujian Province,361000 China)

机构地区：[1]湖北省孝感市中心医院,湖北孝感432000 [2]厦门大学附属翔安医院感染科,福建厦门361000 [3]厦门市感染性疾病质量控制中心,福建厦门361000

出　　处：《系统医学》2023年第7期194-198,共5页Systems Medicine

基　　金：厦门市科技计划指导项目(3502Z2019045)。

摘　　要：乙型肝炎是感染乙型肝炎病毒(hepatitis B virus,HBV)引起肝脏慢性炎症性改变为主要特征的一类传染病。长期慢性感染将导致肝纤维化、肝硬化、肝癌等终末期肝病的发生,严重危害人民群众的健康。慢性乙型肝炎病毒感染依然是全球公共卫生健康问题之一。目前临床上使用的抗病毒治疗方案难以实现对乙型肝炎病毒的彻底清除,其根源在于被感染肝细胞核内持续存在具有稳定结构的共价闭合环状DNA(covalently closed circular DNA,cccDNA)。本文对乙型肝炎病毒共价闭合环状DNA清除的研究进展进行综述,旨在寻找清除cccDNA的途径及办法从而达到乙型肝炎病毒的彻底清除。Hepatitis B is an infectious disease characterized by chronic inflammatory changes in the liver caused by infection with hepatitis B virus(HBV).Long-term chronic infection will lead to the occurrence of liver fibrosis,cirrhosis,liver cancer and other end-stage liver diseases,seriously endangering the health of the people.Chronic hepatitis B virus infection remains one of the global public health problems.The root cause of the difficulty in achieving complete clearance of hepatitis B virus by currently used antiviral treatment regimens is the persistence of covalently closed circular DNA(cccDNA)with a stable structure in the nucleus of infected hepatocytes.This paper review the progress of research on the clearance of covalently closed circular DNA of hepatitis B virus,and aim to find the ways and methods to clear cccDNA so as to achieve the complete clearance of hepatitis B virus.

关 键 词：乙型肝炎病毒 共价闭合环状DNA(cccDNA) 基因 

分 类 号：R59[医药卫生—内科学]