中药及其提取物对感音神经性聋的防治作用研究进展  

Research progress on the preventive and therapeutic effects of traditional Chinese medicine and its extracts on sensorineural hearing loss

作　　者：余鸯鸯 徐飞[1] YU Yangyang;XU Fei(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Zhejiang,Hangzhou 310000,China)

机构地区：[1]浙江中医药大学医学技术与信息工程学院,浙江杭州310000

出　　处：《中国医药科学》2023年第13期51-55,共5页China Medicine And Pharmacy

摘　　要：感音神经性聋(SNHL)是指毛细胞、血管纹、螺旋神经节、听神经或听觉中枢的器质性病变所引起的听力减退或丧失。常见的感音神经性聋有突发性聋、药物性聋、老年性聋、噪声性聋、感染性聋和自身免疫性内耳病。许多研究表明,中药及其提取物能通过增加耳蜗血流量、抗氧化、抗炎、抗凋亡和神经保护活性来治疗感音神经性聋,本文旨在关注中药及其提取物(粉防己碱、水飞蓟素、迷迭香酸、红景天、人参皂苷Rd、仙茅、天麻素、银杏叶二萜内酯、咖啡酸苯乙酯、高良姜素)治疗感音神经性聋(药物性聋、噪声性聋、突发性聋)及其对听觉系统的保护机制。Sensorineural hearing loss(SNHL)refers to hearing impairment or loss caused by organic lesions of hair cells,stria vascularis,spiral ganglion,auditory nerve or auditory center.Common sensorineural hearing loss includes sudden hearing loss,drug-induced hearing loss,age-related hearing loss,noise-induced hearing loss,infectious hearing loss,and autoimmune inner ear disease.Many studies have shown that traditional Chinese medicine and its extracts can treat sensorineural hearing loss by increasing cochlear blood flow and antioxidant,anti-inflammatory,anti-apoptotic,and neuroprotective activities.This article aims to focus on the treatment of sensorineural hearing loss(drug-induced hearing loss,noise-induced hearing loss,sudden hearing loss)with traditional Chinese medicine and its extracts(tetrandrine,silymarin,rosmarinic acid,rhodiola,ginsenoside Rd,curculigo orchioides,gastrodin,ginkgo diterpene lactone,caffeic acid phenethyl ester,galangin)as well as their protective mechanism on the auditory system.

关 键 词：感音神经性聋 中药 中药提取物 噪声性聋 突发性聋 药物性聋 

分 类 号：R276.144[医药卫生—中医五官科学]