益气活血利水法联合乙酰半胱氨酸治疗肝硬化失代偿期腹水的临床效果  

Clinical efficacy of Yiqi Huoxue Lishui method combined with acetylcysteine on decompensated cirrhosis and ascites

作　　者：唐晓路 邓玲 TANG Xiaolu;DENG Ling(Department of Hepatology,Taizhou Hospital of Traditional Chinese Medicine,Jiangsu,Taizhou 225300,China;Department of Internal Medicine,Taizhou Hospital of Traditional Chinese Medicine,Jiangsu,Taizhou 225300,China)

机构地区：[1]江苏省泰州市中医院肝病科,江苏泰州225300 [2]江苏省泰州市中医院内科,江苏泰州225300

出　　处：《中国医药科学》2023年第13期108-111,116,共5页China Medicine And Pharmacy

摘　　要：目的探讨对肝硬化失代偿腹水患者实施益气活血利水法联合乙酰半胱氨酸治疗的临床效果。方法选取泰州市中医院在2019年10月至2022年7月收诊的68例肝硬化失代偿期腹水患者,经中医辨证属于气虚血瘀证,以随机数表法将其分为研究组和对照组,对照组(34例)依照指南首先进行常规对症治疗,同时进行乙酰半胱氨酸治疗,研究组(34例)在对照组基础上联合益气活血利水法治疗,对两组临床效果、肝功能改善情况、腹围、24 h尿量、体重及安全性进行比较。结果研究组治疗总有效率为91.18%,高于对照组的70.58%,差异有统计学意义(P<0.05)。治疗前,两组腹围、24 h尿量、体重差异无统计学意义(P>0.05),治疗后,研究组腹围、体重低于对照组,24h尿量高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肝功能指标差异无统计学意义(P>0.05),治疗后,研究组丙氨酸转氨酶(ALT)、总胆红素(TBil)、天冬氨酸转氨酶(AST)水平低于对照组,白蛋白(Alb)水平高于对照组,差异有统计学意义(P<0.05)。治疗期间两组均安全性良好,未出现严重不良反应。结论对肝硬化失代偿期腹水患者以益气活血利水法联合乙酰半胱氨酸治疗方案进行治疗,其具有良好的效果,可有效改善肝功能,增强利尿效果,稳定病情,安全性高,值得推广。Objective To investigate the clinical efficacy of Yiqi Huoxue Lishui method combined with acetylcysteine in patients with decompensated cirrhosis and ascites.Methods A total of 68 patients with decompensated cirrhosis and ascites admitted to Taizhou Hospital of Traditional Chinese Medicine from October 2019 to July 2022 were selected.They were diagnosed to belong to qi deficiency and blood stasis syndrome according to traditional Chinese medicine(TCM)syndrome differentiation.And they were divided into the study group(n=34)and the control group(n=34)according to the random number table method.The control group was firstly treated with conventional symptomatic treatment according to the guidelines and then added with acetylcysteine,while the study group was treated with Yiqi Huoxue Lishui method on the basis of the treatment in the control group.The clinical efficacy,hepatic function improvement,abdominal circumference,24 h urine volume,body weight and safety of the two groups were compared.Results The total effective rate of the study group was 91.18%,which was higher than 70.58%in the control group,with a statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in abdominal circumference,24-hour urine volume,weight between the two groups(P>0.05).After treatment,the abdominal circumference and body weight of the study group were lower than those of the control group,and the 24-hour urine volume was higher than that of the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in hepatic function indices between the two groups(P>0.05).After treatment,the levels of alanine aminotransferase(ALT),total bilirubin(TBil)and aspartate aminotransferase(AST)in the study group were lower than those in the control group,while albumin(Alb)level was higher than that in the control group,with statistically significant differences.During the treatment,both groups were safe and there were no serio

关 键 词：益气活血利水法 乙酰半胱氨酸 肝硬化腹水 失代偿期 临床效果 肝功能 

分 类 号：R259[医药卫生—中西医结合]