甲哌卡因在TURP术中的临床应用研究  

Clinical application of mepivacaine in TURP surgery

作　　者：阚明威 贾立勇 梁晖 曾德敏 KAN Mingwei;JIA Liyong;LIANG Hui;ZENG Demin(Department of Anesthesiology,the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Guangdong,Zhuhai 519100,China)

机构地区：[1]遵义医科大学第五附属(珠海)医院麻醉科,广东珠海519100

出　　处：《中国医药科学》2023年第13期149-152,共4页China Medicine And Pharmacy

基　　金：广东省珠海市医学科研项目(2220009000128)。

摘　　要：目的探讨甲哌卡因在经尿道前列腺电切术(TURP)中的临床应用。方法前瞻性研究2021年3月至2022年6月于遵义医科大学第五附属(珠海)医院因前列腺增生(BPH)前来就诊,经临床诊断及手术指征明确,需择期行TURP的患者60例,随机分为两组,分别为观察组(n=30)及对照组(n=30)。对照组给予利多卡因+罗哌卡因,观察组给予甲哌卡因。比较两组麻醉时间、效果以及满意度;比较两组患者术中收缩压(SBP)、舒张压(DBP)以及平均动脉压(MAP);比较两组不良反应发生率。结果观察组的感觉及运动阻滞的起效时间较对照组更快,感觉与运动的阻滞持续时间短于对照组,差异有统计学意义(P<0.05)。观察组的麻醉效果和满意度均高于对照组,差异有统计学意义(P<0.05)。T1、T2时观察组的SBP、DBP以及MAP均高于照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异无统计学意义(P>0.05)。结论甲哌卡因骶管阻滞用于TURP术中,起效时间较快,麻醉效果确切,且维持术中血流动力学指标较稳定,安全性较高,且术后感觉及运动功能恢复较快,更有利于患者的快速康复。Objective To explore the clinical application of mepivacaine in transurethral resection of the prostate(TURP).Methods Prospective study from March 2021 to June 2022,60 patients with benign prostatic hyperplasia(BPH)who were admitted to the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University were selected for TURP after clinical diagnosis and surgical indications.They were randomly divided into observation group(n=30)and control group(n=30).The control group was given lidocaine+ropivacaine,and the observation group was given mepivacaine.The anesthesia time,effect and satisfaction of the two groups were compared.The systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean arterial pressure(MAP)were compared between the two groups.The incidence of adverse reactions was compared between the two groups.Results The onset time of sensory and motor block in the observation group was faster than that in the control group,and the blocking time of sensory and motor was shorter than that in the control group,with a statistically significant difference(P<0.05).The anesthesia effect and satisfaction of the observation group were higher than those of the control group,with a statistically significant difference(P<0.05).At T1 and T2,the SBP,DBP,and MAP of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was not statistically significant(P>0.05).Conclusion The use of mepivacaine for the caudal block during TURP surgery have a shorter onset time,precise anesthesia effect,stable intraoperative hemodynamic indexes,higher safety,and faster postoperative recovery of sensory and motor functions,which is more conducive to the rapid recovery of patients.

关 键 词：甲哌卡因 利多卡因 罗哌卡因 TURP 血流动力指标 

分 类 号：R614[医药卫生—麻醉学]