生酮饮食干预多囊卵巢综合征中国专家共识(2022年修订版)  

Chinese expert consensus of ketogenic diet intervention for polycystic ovary syndrome(2022 revision)

作　　者：蔡华[1] 白文佩[2] 郁琦[3] 阮祥燕[4] 杨欣[5] 冯力民[6] 顾蓓[2] 李健[2] 吴洁[7] 张琚[8] 郝丽娟[9] 周寒鹰 杨蕊[11] 高洪伟[11] 陈瑛 张炜[12] 黄元华[13] 张洁 曲庆兰[15] 王允芳 解雁飞[17] 崔玉倩 李增宁[19] 郭增清 周莉[21] 宋新娜[15] 张片红[22] 马向华[7] 郑璇 翁敏 朱翠凤 陈秋霞 戴民慧 黄晓莉[18] 江波 CAI Hua;BAI Wenpei;YU Qi;RUAN Xiangyan;YANG Xin;FENG Limin;GU Bei;LI Jian;WU Jie;ZHANG Ju;HAO Lijuan;ZHOU Hanying;YANG Rui;GAO Hongwei;CHEN Ying;ZHANG Wei;HUANG Yuanhua;ZHANG Jie;QU Qinglan;WANG Yunfang;XIE Yanfei;CUI Yuqian;LI Zengning;GUO Zengqing;ZHOU Li;SONG Xinna;ZHANG Pianhong;MA Xianghua;ZHENG Xuan;WENG Min;ZHU Cuifeng;CHEN Qiuxia;DAI Minhui;HUANG Xiaoli;JIANG Bo(Hunan Provincial People′s Hospital,the First Hospital Affiliated to Hunan Normal University,Changsha,Hunan,410005;Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing,100038;Peking Union Medical College Hospital of Chinese Academy Medical Sciences,Beijing,100005;Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University,Beijing,100006;the People′s Hospital of Peking University,Beijing,100044;Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing,100050;Jiangsu Provincial People′s Hospital,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,210029;Sichuan Provincial Maternity and Child Health Care Hospital,Chengdu,Sichuan,610031;Chongqing Municipal Maternal and Child Health Care Hospital,Chongqing,400013;Northwest Women's and Children′s Hospital in Xi′an City of Shaanxi Province,Xi′an,Shaanxi,710061;the Third Hospital of Peking University,Beijing,100083;Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai,200011;the First Affiliated Hospital of Hainan Medical University,Haikou,Hainan,570102;Dalian City Women and Children Medical Center in Liaoning Province,Dalian,Liaoning,116037;Yantai Yuhuangding Hospital,Yantai,Shandong,264000;Maternal and Child Health Care Hospital of Ningxia Hui Autonomous Region,Yinchuan,Ningxia,750001;the Affiliated Hospital of Yan′an University,Yan′an,Shaanxi,716000;Qilu Hospital of Shandong University,Jinan,Shandong,250012;the First Hospital of Hebei Medical University,Stomatological Hospital,Shijiazhuang,Hebei,050031;Clinical Oncology School of Fujian Medical University,Fujian CanceRHospital,Fuzho

机构地区：[1]湖南省人民医院/湖南师范大学附属第一医院,湖南长沙410005 [2]首都医科大学附属北京世纪坛医院,北京100038 [3]中国医学科学院北京协和医院,北京100005 [4]首都医科大学附属北京妇产医院,北京100006 [5]北京大学人民医院,北京100044 [6]首都医科大学附属北京天坛医院,北京100050 [7]江苏省人民医院/南京医科大学第一附属医院,江苏南京210029 [8]四川省妇幼保健院,四川成都610031 [9]重庆市妇幼保健院,重庆400013 [10]陕西省西安市西北妇女儿童医院,陕西西安710061 [11]北京大学第三医院,北京100083 [12]复旦大学附属妇产科医院,上海200011 [13]海南医学院第一附属医院,海南海口570102 [14]辽宁省大连市妇女儿童医疗中心,辽宁大连116037 [15]烟台毓璜顶医院,山东烟台264000 [16]宁夏回族自治区妇幼保健院,宁夏银川750001 [17]延安大学附属医院,陕西延安716000 [18]山东大学齐鲁医院,山东济南250012 [19]河北医科大学第一医院/口腔医院,河北石家庄050031 [20]福建医科大学肿瘤临床医学院/福建省肿瘤医院,福建福州350005 [21]苏州大学附属第一医院,江苏苏州215031 [22]浙江大学医学院附属第二医院,浙江杭州310009 [23]海军军医大学第一附属医院,上海200433 [24]昆明医科大学第一附属医院,云南昆明650032 [25]南方医科大学深圳医院,广东深圳518110 [26]浙江中医药大学附属第二医院/浙江省新华医院,浙江杭州310005 [27]中南大学湘雅医院,湖南长沙410008

出　　处：《实用临床医药杂志》2023年第11期1-10,共10页Journal of Clinical Medicine in Practice

基　　金：北京市医院管理中心“登峰”计划专项(DFL20190701);北京市医院管理中心临床医学发展专项(ZYLX202112);国家自然科学基金(82073531);吴阶平医学基金会临床科研专项基金(320-6750-2020.06.63)。

摘　　要：多囊卵巢综合征(PCOS)是育龄期女性最常见的妇科内分泌疾病之一。生酮饮食(KD)是一种以低碳水化合物、高脂肪、适量蛋白质为特点的饮食结构。2019年专家组组织了妇科专家和营养专家共同制定并发布了《生酮饮食干预多囊卵巢综合征中国专家共识(2018年版)》。鉴于近5年KD治疗在安全性和应用范围方面出现了大量新的临床数据,专家组决定对《生酮饮食干预多囊卵巢综合征中国专家共识(2018年版)》进行修订和数据更新。主要更新内容有:①更新中国PCOS患病率研究数据;②增加PCOS中的代谢综合征与饮食干预临床证据;③增加KD改善PCOS的循证证据及中国临床研究证据;④增加KD对与PCOS相关代谢综合征影响的循证医学证据;⑤提供短期和长期KD有效性和安全性证据;⑥增加低能量生酮饮食(LCKD)在PCOS中的应用及安全性证据;⑦增加PCOS治疗常用药物联合KD干预效果的证据;⑧完善KD干预PCOS的适应证、禁忌证、不良反应及对策;⑨完善KD中食物种类的选择及操作方法建议。Polycystic ovary syndrome(PCOS)is one of the most common gynecological endocrine diseases in women of childbearing age.Ketogenic diet(KD)is a dietary structure that is characterized by low carbohydrate,high fat and moderate protein.In 2019,the expert group organized a team consisted of gynecotokologists and nutritionists to jointly formulate and release the Chinese Expert Consensus on Ketogenic Diet as Medical Prescription in Polycystic Ovary Syndrome(2018).Since a numbeRof new clinical data on the safety and application of KD therapy have been obtained in the past five years,the expert group decided to revise and update Chinese Expert Consensus on Ketogenic Diet as Medical Prescription in Polycystic Ovary Syndrome(2018).The main updates are as follows:①to update the epidemiological data of PCOS in China;②to increase the clinical evidence of metabolic syndrome and dietary intervention in PCOS patients;③to add evidence-based and new clinical trial evidence of KD in improving PCOS;④to increase the evidence based on evidence-based medicine in impacts of KD on PCOS-associated metabolic syndrome;⑤to provide evidence in short-term and long-term efficacy and safety of KD;⑥to increase the application and safety evidence of low calorie ketogenic diet(LCKD)in PCOS;⑦to increase the evidence of effects by commonly used drugs combined with KD intervention foRPCOS;⑧to improve the indications,contraindications,adverse reactions and countermeasures during KD intervention in PCOS;⑨to improve the selection of food types and provide suggestions on operation methods.

关 键 词：生酮饮食 多囊卵巢综合征 专家共识 生活方式干预 指南 临床营养 

分 类 号：R711.75[医药卫生—妇产科学] R459.3[医药卫生—临床医学]