14省市35家医院药护人员抗肿瘤生物制剂认知现状及护理人员药学需求调研分析  

Investigation and Analysis of the Current Situation of Anti-tumor Biological Awareness and Pharmaceutical Needs of Medical Staff in 35 Hospitals in 14 Provinces and Cities

作　　者：汪皖青 王永[1] 徐颖 杨亚平 陈蓉[1] WANG Wanqing;WANG Yong;XU Ying;YANG Yaping;CHEN Rong(Department of Pharmacy,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Pharmacy,the Third People's Hospital of Yancheng City,Yancheng 224001,China;Department of Pharmacology,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学附属第一医院药学部,苏州215006 [2]盐城市第三人民医院药学部,盐城224001 [3]苏州大学药学院,苏州215123

出　　处：《医药导报》2023年第8期1151-1157,共7页Herald of Medicine

基　　金：苏州市卫生青年骨干人才“全国导师制”培训项目(Qngg2021002);2021年度河南省慢病健康管理重点实验室开放课题项目(HMKF202102);2021年度苏州市科技发展计划(医疗卫生科技创新-应用基础研究[第三批])项目(SKJYD2021160);2022年度江苏省药学会-正大天晴医院药学科研基金立项(Q202230)。

摘　　要：目的调研药护人员对抗肿瘤生物制剂的认知并探讨护理人员药学需求和认知影响因素,为抗肿瘤生物制剂临床合理使用和药学服务提供参考。方法采用问卷调研药护人员对西妥昔单抗、贝伐珠单抗、曲妥珠单抗、利妥昔单抗、信迪利单抗及卡瑞利珠单抗6种生物制剂的认知现状及护理人员药学需求,内容包括:基本情况、药物知识认知、药物配置和临床输注认知及护理人员药学需求。结果①共调研14省、市35家医院495人(药师112人、护理人员383人);②药物配置地点以病区和静脉药物调配中心均配置(51.43%)和病区配置(42.86%)为主,62.86%应用生物安全柜配置,80%按照配置细胞毒药物标准防护,24家医院已上线移动护理系统;③除贝伐珠单抗外,护理人员对其他5种药物适应证认知均高于药师,其中对西妥昔单抗、曲妥珠单抗、信迪利单抗及卡瑞利珠单抗认知差异有统计学意义(P<0.05),对利妥昔单抗认知差异无统计学意义(P>0.05);护理人员对6种药物用法用量认知均显著高于药师(P<0.05);④药物配置与输注:护理人员对配置前目测药液/药粉认知均高于药师,其中西妥昔单抗认知差异有统计学意义(P<0.05),其他差异无统计学意义(P>0.05);除贝伐珠单抗除外,护理人员对轻轻翻转混匀认知均高于药师,但差异无统计学意义(P>0.05);护理人员对配置西妥昔单抗和利妥昔单抗终浓度要求认知高于药师(P<0.05),对配置贝伐珠单抗和信迪利单抗终浓度要求认知低于药师(P<0.05);护理人员对配置后溶液储存要求认知均高于药师,但差异无统计学意义(P>0.05);83.95%以上护理人员知晓药物输注要求;⑤医院级别及是否有移动护理系统、药物配置条件及地点、护理人员性别、对药物了解程度及参加培训次数均影响护理人员认知;⑥76.50%以上护理人员有不同方面的药学需求。结论药护人员对抗肿瘤生物制剂�Objective To investigate the perceptions of pharmacists and nursing staff on anti-tumor biological agents and explore the pharmaceutical needs and influencing factors of cognition of nursing staff,to provide a reference for the rational use of anti-tumor biological agents and pharmaceutical services.Methods A questionnaire was conducted to investigate the cognitive status of six biological agents,including cetuximab,bevacizumab,trastuzumab,rituximab,sintilimab,and camrelizumab,and the pharmaceutical needs of nursing staff,including basic information,drug knowledge,drug configuration and clinical infusion cognition,and the pharmaceutical needs of nursing staff.Results①495 staff(112 pharmacists and 383 nurses)from 35 hospitals in 14 provinces and cities were investigated;②The drug admixture locations are mainly in both the ward and pharmacy intravenous admixture services(51.43%),or only in the ward(42.86%),62.86% of which are admixtured in the biosafety cabinets,and 80% of which are protected according to the standard for admixturing cytotoxic drugs,and 24 hospitals have launched mobile nursing systems;③Except for bevacizumab,the cognition of nursing staff on the indications of six drugs was higher than that of pharmacists.Among them,the cognitive differences of cetuximab,trastuzumab,sintilimab and camrelizumab were statistically significant(P<0.05),while the cognitive differences of rituximab were not statistically significant(P>0.05);nurses'cognition of the usage and dosage of the six drugs was significantly higher than that of pharmacists(P<0.05);④Drug admixture and infusion:the cognition of nursing staff on the visual examination of the liquid/powder before admixture was higher than that of pharmacists,among which the cognition of cetuximab was statistically different(P<0.05);with the exception of bevacizumab,the cognition of nursing staff to gently flip mixing was higher than that of pharmacists,but there was no statistical difference(P>0.05);nursing staff have higher cognition of the final concentrati

关 键 词：抗肿瘤生物制剂 药师 护理人员 抗肿瘤生物制剂认知 药学需求 

分 类 号：R951[医药卫生—药学] R979.1