甲巯咪唑致胰岛素自身免疫综合征一例  

Insulin autoimmune syndrome induced by thiamazole:a case report

作　　者：刘美芹 窦建新 马启航 高素敏 马静怡 刘海霞[2] LIU Mei-qin;DOU Jian-xin;MA Qi-hang;GAO Su-min;MA Jing-yi;LIU Hai-xia(School of Clinical Medicine,Weifang Medical University,Shandong Weifang 261000,China;Department of Endocrinology,Weifang People's Hospital,Shandong Weifang 261000,China)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261000 [2]潍坊市人民医院内分泌科,山东潍坊261000

出　　处：《临床药物治疗杂志》2023年第6期90-92,共3页Clinical Medication Journal

摘　　要：胰岛素自身免疫综合征是导致低血糖的临床罕见病因,与人类白细胞抗原(HLA)基因密切相关,常合并自身免疫病,通常由含有巯基的药物诱发。本文报道1例甲巯咪唑诱发的胰岛素自身免疫综合征的病例,HLA基因为HLA-(DRB1^(*)0406、DQB1^(*)0303、DQA1^(*)0303),停用甲巯咪唑,调整饮食结构并加用阿卡波糖治疗后,患者的血糖水平逐渐平稳。Insulin autoimmune syndrome is a rare clinical cause of hypoglycemia.It is closely related to human leukocyte antigen(HLA) genes and is often associated with autoimmune diseases.It is usually induced by drugs containing sulfhydryl groups.A case of insulin autoimmune syndrome induced by thiamazole was reported in this article.The HLA genes of the patient were HLA-(DRB1^(*)0406,DQB1^(*)0303,DQA1^(*)0303).After withdrawal of thiamazole,diet modification and acarbose treatment were given,and the patient's blood glucose level got stabilized gradually.

关 键 词：甲巯咪唑 胰岛素自身免疫综合征 胰岛素自身抗体 低血糖 

分 类 号：R969.3[医药卫生—药理学]