Th17和Treg在毛细支气管炎与喘息性支气管炎中表达的意义  

Significance of Th17 and Treg expression in bronchiolitis and asthmatic bronchitis

作　　者：商丽娜 郭军[1] 李宁[1] 丁锐[1] SHANG Li-na;GUO Jun;LI Ning(Department of Intensive Care Medicine,Dalian Children's Hospital,Dalian 116200,China)

机构地区：[1]辽宁省大连市儿童医院重症医学科,116200

出　　处：《中国实用医药》2023年第13期33-35,共3页China Practical Medicine

基　　金：Th17和Treg在毛细支气管炎与喘息性支气管炎中表达的意义(项目编号:1811077)。

摘　　要：目的 探讨毛细支气管炎与喘息性支气管炎患儿中外周血辅助性T淋巴细胞17(Th17)、调节性T淋巴细胞(Treg)表达的意义。方法 选取83例诊断为毛细支气管炎患儿作为研究对象,其中呼吸科病房住院并诊断为普通毛细支气管炎的患儿66例作为普通组,根据随访1年后是否喘息再次发作分为A组(42例,未喘息再次发作)和B组(24例,喘息再次发作);ICU住院并诊断为毛细支气管炎合并呼吸衰竭或(和)心力衰竭的患儿17例作为C组。检测三组患儿的Th17、Treg水平。分析患儿喘息再次发作情况,比较三组患儿静脉血Th17、Treg水平。结果 83例患儿中共发生再次喘息发作38例(45.78%),其中普通组24例,C组14例。既往有湿疹和(或)鼻炎患儿12例,发生再次喘息发作9例(75.00%);家族有湿疹、喘息、过敏等疾病病史者7例,发生再次喘息发作4例(57.14%)。A组患儿静脉血Th17(3.68±0.45)%低于B组的(4.42±0.60)%和C组的(4.79±0.63)%,Treg(10.65±0.90)%高于B组的(7.93±1.25)%和C组的(7.39±1.09)%,差异均具有统计学意义(P<0.05)。B组和C组Th17、Treg水平比较,差异均无统计学意义(P>0.05)。结论 Treg与Th17之间的平衡在毛细支气管炎的发病机制中起着重要作用,对预防并发症及喘息再次发作具有重要意义,为患儿早期进行免疫干预治疗,减轻临床症状及体征,减少喘息性支气管炎的发病率提供理论依据。Objective To discuss the significance of helper T cell 17(Th17)and regulate T lymphocytes(Treg)expression in bronchiolitis and asthmatic bronchitis.Methods 83 children diagnosed with bronchiolitis were selected for the study,of which 66 children hospitalized in the respiratory ward and diagnosed with common bronchiolitis were classified as the general group and divided into group A(42 children without recurrence of wheezing)and group B(24 children with recurrence of wheezing)according to whether they experienced a recurrence of wheezing after 1 year of follow-up;17 children who were hospitalized in the ICU and diagnosed with bronchiolitis combined with respiratory failure and/or heart failure were selected as group C.Th17 and Treg levels were measured in the three groups of children.The recurrence of wheezing was analyzed,and the venous blood Th17 and Treg levels were compared among the three groups.Results A total of 38(45.78%)of the 83 children had recurrence of wheezing,including 24 cases in the general group and 14 cases in the C group.There were 12 cases of children with previous eczema and/or rhinitis,of which 9 cases(75.00%)had recurrence of wheezing;7 cases with family history of eczema,wheezing and allergy,of which 4 cases(57.14%)had recurrence of wheezing.Th17 of(3.68±0.45)%in venous blood of group A were lower than that of(4.42±0.60)%in group B and(4.79±0.63)%in group C;Treg of(10.65±0.90)%in group A was higher than that of(7.93±1.25)%in group B and(7.39±1.09)%in group C;all the differences were statistically significant(P<0.05).There were no statistically significant differences in Th17 and Treg levels between group B and group C(P>0.05).Conclusion The balance between Treg and Th17 plays an important role in the pathogenesis of bronchiolitis,and is of great significance in preventing complications and wheezing recurrence in children,providing a theoretical basis for early immunization intervention,reducing clinical symptoms and signs,and reducing the incidence of asthmatic bronchitis.

关 键 词：毛细支气管炎 喘息性支气管炎 外周血辅助性T淋巴细胞17 调节性T淋巴细胞 

分 类 号：R725.6[医药卫生—儿科]