左氧氟沙星联合甲泼尼龙对老年重症肺炎患者免疫功能及炎症反应的影响  

Effects of levofloxacin combined with methylprednisolone on immune function and inflammatory response in elderly patients with severe pneumonia

作　　者：吴志萍 刘信红 WU Zhi-ping;LIU Xin-hong(Department of Intensive Care Medicine,Yantai Laiyang Central Hospital,Yantai 265200,China)

机构地区：[1]烟台市莱阳中心医院重症医学科,265200

出　　处：《中国实用医药》2023年第13期83-85,共3页China Practical Medicine

摘　　要：目的 探讨左氧氟沙星联合甲泼尼龙对老年重症肺炎患者免疫功能及炎症反应的影响。方法 80例老年重症肺炎患者,按照随机数字表法分为对照组和观察组,每组40例。两组均给予常规治疗,对照组在其基础上给予甲泼尼龙治疗,观察组在对照组基础上给予左氧氟沙星治疗。比较两组临床疗效及治疗前后免疫功能、炎性因子水平。结果 治疗后,观察组总有效率85.00%高于对照组的65.00%,差异有统计学意义(P<0.05)。治疗后,两组血清CD4^(+)、CD4^(+)/CD8^(+)水平均高于本组治疗前,血清CD8^(+)水平均低于本组治疗前,且观察组血清CD4^(+)水平(44.26±3.58)%、CD4^(+)/CD8^(+)水平(2.00±0.52)高于对照组的(39.31±5.62)%、(1.46±0.34),血清CD8^(+)水平(22.18±4.69)%低于对照组的(26.97±5.37)%,差异有统计学意义(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)水平均明显低于本组治疗前,血清白细胞介素-10(IL-10)水平均明显高于本组治疗前,且观察组血清IL-6水平(126.57±32.51)ng/L低于对照组的(161.32±30.46)ng/L,血清IL-10水平(19.64±4.61)ng/L高于对照组的(17.58±2.41)ng/L,差异有统计学意义(P<0.05)。结论 左氧氟沙星联合甲泼尼龙可明显改善老年重症肺炎患者机体炎症状态,提高免疫功能,临床疗效显著。Objective To discuss the effects of levofloxacin combined with methylprednisolone on immune function and inflammatory response in elderly patients with severe pneumonia.Methods A total of 80 elderly patients with severe pneumonia were divided into control group and observation group according to random numerical table,with 40 cases in each group.Both groups were given conventional treatment.On this basis,the control group was treated with methylprednisolone,and the observation group was treated with levofloxacin.The clinical efficacy,immune function and inflammatory factor levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was 85.00%,which was higher than that of 65.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of CD4^(+)and CD4^(+)/CD8^(+)in both groups were higher than before treatment in this group,and serum level of CD8^(+)was lower than that before treatment in this group;the serum levels of CD4^(+)and CD4^(+)/CD8^(+)were(44.26±3.58)%and(2.00±0.52)in the observation group,which were higher than those of(39.31±5.62)%and(1.46±0.34)in the control group;the serum level of CD8^(+)of(22.18±4.69)%in the observation group was lower than that of(26.97±5.37)%in the control group;the differences were statistically significant(P<0.05).After treatment,the serum level of interleukin-6(IL-6)in both groups was significantly lower than that before treatment in this group,and the serum level of interleukin-10(IL-10)was significantly higher than that before treatment in this group;the serum level of IL-6 of(126.57±32.51)ng/L in the observation group was lower than that of(161.32±30.46)ng/L in the control group;serum level of IL-10 of(19.64±4.61)ng/L in the observation group was higher than that of(17.58±2.41)ng/L in the control group;the differences were statistically significant(P<0.05).Conclusion Levofloxacin combined with methylprednisolone can significan

关 键 词：重症肺炎 老年 左氧氟沙星 甲泼尼龙 免疫功能 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]