持续皮下胰岛素输注治疗糖尿病酮症的效果观察  

Effect observation of continuous subcutaneous insulin infusion in the treatment of diabetic ketosis

作　　者：王娜 WANG Na(Shandong Guoxin Yiyang Group Tengnan Hospital,Tengzhou 277500,China)

机构地区：[1]山东省国欣颐养集团滕南医院,277500

出　　处：《中国实用医药》2023年第13期117-120,共4页China Practical Medicine

摘　　要：目的 探究持续皮下胰岛素输注(CSII)治疗糖尿病酮症的临床效果。方法 60例糖尿病酮症患者,发放随机信封根据单双号分为观察组与对照组,各30例。观察组采用持续皮下胰岛素输注治疗,对照组采用持续静脉胰岛素输注(CVII)治疗。比较两组患者临床症状改善情况、血糖指标、临床疗效及低血糖发生率。结果 观察组血糖达标时间(4.45±1.46)h、尿酮体转阴时间(32.35±6.23)h、β-羟丁酸恢复正常时间(19.48±4.75)h均短于对照组的(7.42±1.53)、(43.45±7.84)、(25.54±5.62)h,胰岛素用量(42.55±5.32)U/d少于对照组的(51.55±6.73)U/d,差异有统计学意义(P<0.05)。治疗前,两组空腹血糖、餐后2 h血糖比较差异无统计学意义(P>0.05);治疗后,两组空腹血糖、餐后2 h血糖均低于治疗前,且观察组空腹血糖(7.42±1.04)mmol/L、餐后2 h血糖(9.05±1.15)mmol/L均低于对照组的(9.26±1.46)、(12.54±1.36)mmol/L,差异有统计学意义(P<0.05)。观察组总有效率93.3%显著高于对照组的70.0%,差异有统计学意义(P<0.05)。观察组低血糖发生率为3.33%(1/30),低于对照组的26.67%(8/30),差异有统计学意义(P<0.05)。结论 CSII治疗糖尿病酮症,在改善患者血糖指标及促进尿酮体方面有着突出效果,有利于疾病转归、减少低血糖的发生,可予以推广。Objective To investigate the clinical effect of continuous subcutaneous insulin infusion(CSII)in the treatment of diabetic ketosis.Methods A total of 60 cases of diabetic ketosis patients were randomly divided into observation group and control group according to odd-even numbers,with 30 cases in each group.The observation group was treated with continuous subcutaneous insulin infusion,while the control group was treated with continuous venous insulin infusion(CVII).The improvement of clinical symptoms,blood glucose index,clinical efficacy and incidence of hypoglycemia were compared between the two groups.Results The observation group had time for blood glucose return to normal of(4.45±1.46)h,the negative conversion time of urine ketone body of(32.35±6.23)h and the time forβ-hydroxybutyric acid return to normal of(19.48±4.75)h,which were shorter than those of(7.42±1.53),(43.45±7.84)and(25.54±5.62)h in the control group;the dosage of insulin of(42.55±5.32)U/d in the observation group was lower than that of(51.55±6.73)U/d in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in fasting blood glucose and 2 h postprandial blood glucose between the two groups(P>0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose in both groups were lower than those before treatment in this group;and fasting blood glucose of(7.42±1.04)mmol/L and 2 h postprandial blood glucose of(9.05±1.15)mmol/L in the observation group were lower than those of(9.26±1.46)and(12.54±1.36)mmol/L in the control group;the differences were statistically significant(P<0.05).The total effective rate of 93.3%in the observation group was significantly higher than that of 70.0%in the control group,and the difference was statistically significant(P<0.05).The incidence of hypoglycemia was 3.33%(1/30)in the observation group,which was lower than that of 26.67%(8/30)in the control group,and the difference was statistically significant(P

关 键 词：持续皮下胰岛素输注 糖尿病酮症 血糖 血酮体 

分 类 号：R587.2[医药卫生—内分泌]