我院291例药物不良反应报告回顾性分析  

Retrospective analysis of 291 cases of adverse drug reactions in our hospital

作　　者：庞旭静 高青青[1] 张立刚[1] 鲍晓龙 徐玉晨 PANG Xu-jing;GAO Qing-qing;ZHANG Li-gang(Department of Pharmacy,Fengtai You Anmen Hospital,Beijing 100069,China)

机构地区：[1]北京丰台右安门医院药剂科,100069

出　　处：《中国实用医药》2023年第13期157-159,共3页China Practical Medicine

摘　　要：目的 分析本院药物不良反应(ADR)的发生情况,为促进临床合理用药提供参考。方法 回顾性分析本院2018~2021年上报的ADR情况,对发生的ADR类型、患者性别与年龄、发生ADR的药品情况、给药途径、ADR累及器官/系统及主要临床表现进行总结。结果 291例ADR报告中,新的ADR、严重ADR、一般ADR分别为7、10、274例;男168例(57.73%)、女123例(42.27%);>65岁患者占比最高(58.42%);导致ADR的药品主要为抗菌药物;引发ADR的给药途径以静脉滴注最多,占76.63%;ADR累及器官/系统最多的为皮肤及其附件,占47.08%;碘造影剂(碘普罗胺注射液、碘克沙醇注射液)导致的严重ADR发生率最高,占30.00%。结论 临床应加强ADR监测及上报工作,提升用药安全意识,保障患者用药安全。Objective To analyze the occurrence of adverse drug reactions(ADR)in our hospital,so as to provide reference for promoting clinical rational drug use.Methods The ADR reported in our hospital from 2018 to 2021 were analyzed retrospectively,and the types of ADR,gender and age of patients,drug situation in which ADR occurred,route of administration,organs/systems involved in ADR and main clinical manifestations were summarized.Results Among the 291 reported ADR cases,there were 7,10 and 274 cases of new ADR,severe ADR and general ADR,respectively;168 cases(57.73%)in men and 123 cases(42.27%)in women;the highest percentage of patients aged≥65 years(58.42%);the drugs causing ADR were mainly antibacterial drugs;intravenous infusion was the most common route of ADR,accounting for 76.63%;the organs/systems most involved in ADR were skin and its accessories,accounting for 47.08%;the incidence of serious ADR caused by iodine contrast agents(iopromide injection,iodixanol injection)was the highest,accounting for 30.00%.Conclusion Clinical monitoring and reporting of ADR should be strengthened to raise awareness of medication safety and ensure patient medication safety.

关 键 词：药物不良反应 用药安全 临床分析 

分 类 号：R969.3[医药卫生—药理学]