多巴胺与卡托普利联合治疗小儿肺炎合并心力衰竭疗效观察  

Observation on the effect of dopamine combined with captopril in the treatment of pediatric pneumonia complicated with heart failure

作　　者：张玉松 Zhang Yusong(The Third Affiliated Hospital of Zunyi Medical University(The First People's Hospital of Zunyi),Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学第三附属医院(遵义市第一人民医院),贵州遵义563000

出　　处：《首都食品与医药》2023年第13期47-49,共3页Capital Food Medicine

摘　　要：目的分析多巴胺与卡托普利联合治疗小儿肺炎合并心力衰竭的临床疗效。方法选取2021年9月-2022年8月遵义市第一人民医院收治的100例小儿肺炎合并心力衰竭患儿进行研究,随机分为两组,对照组给予常规治疗,观察组在此基础上采用多巴胺与卡托普利联合治疗,治疗结束后比较两组患儿临床体征和心肌酶改善情况、临床疗效。结果治疗后,两组患儿心率(HR)、呼吸频率(RR)及血氧饱和度(SaO2)均较治疗前明显改善,其中治疗后观察组HR、RR均低于对照组,SaO2高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿心肌酶指标均较治疗前改善,其中观察组乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)均低于对照组,差异有统计学意义(P<0.05)。观察组住院时间、HR恢复正常时间、RR恢复正常时间及啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论在常规治疗基础上采用多巴胺与卡托普利联合治疗,有助于快速改善小儿肺炎合并心力衰竭患儿的临床体征,减轻心肌损害。Objective To investigate the effect of dopamine combined with captopril in the treatment of pediatric pneumonia complicated with heart failure.Methods 100 cases of pediatric pneumonia and heart failure admitted to Zunyi First People's Hospital from September 2021 to August 2022 were randomly divided into two groups and the control group was treated with routine treatment,the observation group was treated with dopamine and captopril on this basis,after treatment,the clinical signs and myocardial enzyme improvement,clinical efficacy and safety of the two groups were compared.Results After treatment,the heart rate(HR),respiratory rate(RR)and blood oxygen saturation(SaO2)of the two groups were significantly improved compared with those before treatment,and the HR and RR of the observation group were lower than those of the control group,and the SaO2 was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the indexes of myocardial enzymes in the two groups were improved compared with those before treatment,and the lactate dehydrogenase(LDH),aspartate aminotransferase(AST),creatine kinase(CK)and creatine kinase isoenzyme(CK-MB)in the observation group were significantly lower than those in the control group(P<0.05).The hospitalization time,HR recovery time,RR recovery time and rale disappearance time of the observation group were shorter than those of the control group,with statistical significance(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Combined treatment of dopamine and captopril on the basis of routine treatment can help rapidly improve the clinical signs of children with pneumonia and heart failure,reduce myocardial damage.

关 键 词：小儿肺炎 心力衰竭 卡托普利 多巴胺 

分 类 号：R725.6[医药卫生—儿科]