慢性乙型肝炎合并抑郁症的影响因素分析  

Analysis of influencing factors of chronic hepatitis B combined with depression

作　　者：林文清 谢维宁 LIN Wenqing;XIE Weining(School of Public Health and Management,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510006,China;Department of Infectious Disease,Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Guangdong Province,Foshan 510632,China)

机构地区：[1]广州中医药大学公共卫生与管理学院,广东广州510006 [2]广东省中西医结合医院感染科,广东佛山510632

出　　处：《中国当代医药》2023年第21期105-109,共5页China Modern Medicine

基　　金：广东省医学科研基金项目(B2021265);广东省佛山市医学类科技攻关项目(2014AB000872)。

摘　　要：目的探讨慢性乙型肝炎合并抑郁症的影响因素。方法选取2022年1月至2023年1月在广东省中西医结合医院感染科门诊就诊的慢性乙型肝炎人群作为研究对象,采用问卷调查的方式,采集人群资料包括年龄、性别、体重、婚姻状况、烟酒史、教育情况等一般资料及中医体质辨析、中医证型分析及抑郁症评分等,运用logistic回归分析慢性乙型肝炎合并抑郁症的影响因素。结果最终有365例患者纳入研究,其中抑郁症患者96例,无抑郁症患者299例。单因素分析结果显示,不同中医体质类型、中医辨证分型及抑郁症家族史的抑郁症情况比较,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,气郁质(OR=5.579,95%CI:2.063~15.087)、瘀血质(OR=5.590,95%CI:2.009~15.553)、肝郁脾虚型(OR=4.875,95%CI:1.696~14.013)、肝郁痰阻型(OR=6.515,95%CI:2.343~18.119)、肝郁气滞型(OR=4.282,95%CI:1.555~11.791)及有抑郁症家族史(OR=18.847,95%CI:5.416~65.584)是慢性乙型肝炎合并抑郁症的独立危险因素(P<0.05)。结论抑郁症家族史、气郁质、瘀血质及肝郁脾虚型、肝郁痰阻型及肝郁气滞型是慢性乙型肝炎合并抑郁症的独立危险因素,临床中需重视具备上述高危因素,为临床干预提供一定参考价值。Objective To investigate the influencing factors of chronic hepatitis B combined with depression.Methods A population of chronic hepatitis B patients who admitted to the Department of Infectious Disease of Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to January 2023 were selected as the research subjects.By using a questionnaire survey,general information such as age,gender,weight,marital status,smoking and drinking history,education status,as well as traditional Chinese medicine constitution analysis,traditional Chinese medicine syndrome analysis and depression score were collected.Use logistic regression to analyze the influencing factors of chronic hepatitis B complicated with depression.Results A total of 365 patients were ultimately included in the study,including 96 patients with depression and 299 patients without depression.The results of univariate analysis showed that there were statistically significant differences in the comparison of depression among different types of traditional Chinese medicine constitution,traditional Chinese medicine syndrome differentiation and family history of depression(P<0.05).The results of multivariate logistic regression analysis showed that Qi stagnation(OR=5.579,95%CI:2.063-15.087),blood stasis(OR=5.590,95%CI:2.09-15.553),liver depression and spleen deficiency(OR=4.875,95%CI:1.696-14.013),liver depression and phlegm obstruction(OR=6.515,95%CI:2.343-18.119),liver stagnation and Qi stagnation(OR=4.282,95%CI:1.555-11.791)and family history of depression(OR=18.847,95%CI:5.416-65.584)were independent risk factors for chronic hepatitis B complicated with depression(P<0.05).Conclusion Family history of depression,Qi stagnation,blood stasis,liver stagnation and spleen deficiency,liver stagnation and phlegm obstruction,liver stagnation and Qi stagnation are independent risk factors for chronic hepatitis B complicated with depression.It is necessary to pay attention to these high-risk factors in clinical practice and prov

关 键 词：慢性乙型肝炎 抑郁症 中医体质 影响因素 

分 类 号：R512.62[医药卫生—内科学]