针刺治疗精神分裂症阴性症状临床疗效评价  

Clinical efficacy evaluation of acupuncture in treating negative symptoms of schizophrenia

作　　者：李鸿 吕钦谕[2] 易正辉[2] 吴嘉容[3] LI Hong;LYU Qinyu;YI Zhenghui;WU Jiarong(Shanghai Baoshan District Mental Health Center,Shanghai 201900,China;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海市宝山区精神卫生中心,上海201900 [2]上海交通大学医学院附属精神卫生中心,上海201108 [3]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《上海中医药大学学报》2023年第3期8-12,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫计委综合医院中西医结合专项建设项目(ZHYY-ZXYJHZX-2-201708);上海市宝山区科委科技创新专项项目(20-E-41)。

摘　　要：目的:探讨针刺治疗对精神分裂症患者阴性症状的疗效,为临床治疗提供依据。方法:纳入100例以阴性症状为主的精神分裂症患者,采用随机数字表分为研究组和对照组,每组各50例。两组患者均给予氨磺必利片口服治疗,在此基础上,研究组患者给予针刺治疗,观察周期为12周。治疗前后,采用阳性与阴性症状量表(PANSS)、阴性症状量表(SANS)评价两组患者的精神分裂症阴性症状的改善情况。结果:研究过程中,研究组4例患者剔除或脱落,最终纳入统计分析者研究组46例、对照组50例。治疗后,研究组患者的PANSS阴性症状、阳性症状、一般精神病理症状评分及总分较治疗前均明显降低(P<0.01),对照组患者的阴性症状评分亦降低(P<0.05),且研究组患者的阴性症状、一般精神病理症状评分及总分均明显低于对照组(P<0.01)。治疗后,研究组患者的SANS各项评分较治疗前均明显降低(P<0.01),对照组患者的各项评分与治疗前比较差异均无统计学意义(P>0.05),且研究组患者的各项评分均低于对照组(P<0.05,P<0.01)。结论:与单纯采用抗精神病药物治疗相比,针刺联合抗精神病药物能够更好地改善精神分裂症患者的阴性症状,具有一定的临床应用价值。Objective:To explore the therapeutic effect of acupuncture on negative symptoms in patients with schizophrenia and provide the evidence for clinical treatment.Methods:A total of 100 schizophrenic patients with negative symptoms were included and divided into the study group and control group by random number table,50 cases in each group.The patients in both groups were orally treated with amsulpiride tablets.Based on above,the patients in the study group were treated with acupuncture.The observation period was 12 weeks.Before and after treatment,the positive and negative syndrome scale(PANSS)and scale for assessment of negative symptoms(SANS)were applied to evaluate the improvement of negative symptoms of schizophrenia in both groups.Results:During the study,4 patients in the study group were removed or shed off,and 46 patients in the study group and 50 patients in the control group were finally included in the statistical analysis.After treatment,the negative symptom,positive symptom,general psychopathological symptom scores and total score of PANSS in the study group were significantly decreased compared with those before treatment(P<0.01),the negative symptom score in the control group was also decreased(P<0.05),and the negative symptom,general psychopathological symptom scores and total score of the study group were significantly lower than those of the control group(P<0.01).After treatment,the scores of all items of SANS in the study group were significantly decreased compared with those before treatment(P<0.01),while there were no statistically significant differences on the scores of all items in the control group between before and after treatment(P>0.05),and the scores of all items in the study group were lower than those in the control group(P<0.05,P<0.01).Conclusion:Compared with antipsychotic drugs alone,acupuncture combined with antipsychotic drugs can better improve the negative symptoms of patients with schizophrenia,which has certain clinical application value.

关 键 词：精神分裂症 阴性症状 针刺 阳性与阴性症状量表 

分 类 号：R246.6[医药卫生—针灸推拿学]