人参皂苷相关代谢产物抗肿瘤机制的研究进展  

Research progress on antitumor mechanism of ginsenoside⁃related metabolites

作　　者：陈丹青 郑艳艳 郭静 许庆娟 张利[2] 吴咏梅 王源[2] CHEN Danqing;ZHENG Yanyan;GUO Jing;XU Qingjuan;ZHANG Li;WU Yongmei;WANG Yuan(Shanghai SPH Shenxiang Health Co.Ltd.,Shanghai 200336,China;Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海上药神象健康药业有限公司,上海200336 [2]上海中医药大学创新中药研究院,上海201203

出　　处：《上海中医药大学学报》2023年第3期83-91,共9页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家重点研发计划“中医药现代化研究”专项(2017YFC1702301)。

摘　　要：人参作为名贵中药材,具有抗肿瘤等多种药理活性,其有效成分主要为人参皂苷。已知人参皂苷以达玛烷型四环三萜类皂苷为主,包括原人参二醇型和原人参三醇型皂苷。此类原型成分口服后难以直接被人体吸收利用,在肠道菌群作用下水解生成的次级人参皂苷或苷元才能被人体吸收利用。近年来研究显示,原人参二醇型皂苷主要通过肠道菌群转化为人参皂苷CK、Rh2和原人参二醇(PPD),而原人参三醇型皂苷则可经肠道菌群转化为人参皂苷Rh1、F1和PPT,其代谢产物往往表现出比原型人参皂苷更强的抗肿瘤活性。以人参皂苷在肠道菌群干预下的脱糖基作用为切入点,梳理归纳其代谢途径,并对相关代谢产物的抗肿瘤机制进行总结,为人参皂苷在抗肿瘤方面的开发应用提供科学依据。Ginseng,as a valuable traditional Chinese medicine,has a variety of pharmacological activities,and its active ingredient is mainly ginsenoside.Ginsenosides are mainly known as dammarane type tetracyclic triterpenoid saponins,including protopanaxadiol and protopanaxatriol saponins,which are difficult to be absorbed and utilized directly by human body after oral administration.But the scondary ginsenosides or aglycones generated by hydrolysis under the action of intestinal flora can be absorbed and utilized by the human body.Recent studies have shown that protopanaxadiol saponins can be converted into ginsenosides CK,Rh2 and protopanaxadiol(PPD)mainly by intestinal flora,while protopanaxatriol saponins can be converted into ginsenosides Rh1,F1 and PPT by intestinal flora,and the metabolites often show stronger antitumor activity than the prototype ginsenosides.The deglycosylation of ginsenosides by intestinal flora was used as an entry point to sort out their metabolic pathways and summarize the anti-tumor mechanisms of related metabolites,providing a scientific basis for the development and application of ginsenosides in antitumor fields.

关 键 词：人参皂苷 肠道菌群 代谢产物 抗肿瘤 

分 类 号：R285[医药卫生—中药学]