快速康复护理联合益生菌营养疗法对胰腺癌根治术后患者的影响  

Effect of rapid rehabilitation nursing combined with probiotic nutrition therapy on patients with pancreatic cancer after radical operation

作　　者：姜丽[1] 赵磊[1] 黄澜[1] 冬雪[2] 宋莹 刘璐[1] JIANG Li;ZHAO Lei;HUANG Lan;DONG Xue;SONG Ying;LIU Lu(Tumor and Laparoscopic Surgery,the First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China;不详)

机构地区：[1]哈尔滨医科大学附属第一医院肿瘤与腔镜外科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一医院微创胆道外科,黑龙江哈尔滨150001

出　　处：《中国微生态学杂志》2023年第5期573-578,共6页Chinese Journal of Microecology

基　　金：国家自然科学基金(81902421)。

摘　　要：目的探讨快速康复护理联合益生菌营养疗法对胰腺癌根治术后患者营养状况和康复情况的影响。方法选择2020年1月至2022年2月在我院接受胰腺癌根治术的100例患者作为研究对象,采用随机数表法将其分为对照组(n=50)和试验组(n=50)。对照组患者接受胰腺癌根治术常规护理和营养支持,试验组在此基础上施行快速康复护理联合益生菌营养疗法。比较干预前后两组患者转铁蛋白(TRF)、前清蛋白(PAB)、白蛋白(ALB)等营养指标水平,以及免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)等免疫功能指标水平。同时记录干预期间两组患者的腹腔感染、消化道出血、吻合口瘘、切口感染等并发症发生情况,以及住院时间、下床活动时间、肛门排气时间和干预满意率,以评价干预效果。结果干预前,两组患者TRF、PAB、ALB、IgA、IgG和IgM水平比较差异均无统计学意义(均P>0.05)。干预后,试验组患者TRF、PAB、ALB、IgA、IgG和IgM水平均高于对照组(均P<0.05)。干预期间,试验组患者术后并发症总发生率、术后肛门排气时间、下床活动时间和住院时间均低于对照组(均P<0.05)。此外,试验组患者总干预满意率(96.0%)显著高于对照组(80.0%),差异有统计学意义(P<0.05)。结论快速康复护理联合益生菌营养疗法可有效降低胰腺癌根治术后患者并发症发生率,保障患者的营养状况,提高免疫功能,促进术后康复,值得在临床推广应用。Objective To observe the effects of rapid rehabilitation nursing combined with probiotic nutrition therapy on the nutritional status and rehabilitation of patients with pancreatic cancer(PC)after surgery.Methods A total of 100 patients who underwent radical resection of PC in our hospital from January 2020 to February 2022 were enrolled and divided into control group(n=50)and observation group(n=50)randomly.Both groups were given conventional nursing and nutritional support for radical operation of PC,and the patients in the observation group were additionally given rapid rehabilitation nursing combined with probiotic nutritional therapy.The nutritional indexes such as transferrin(TRF),parvalbumin(PAB)and albumin(ALB),and immune function indexes such as immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were compared between the two groups before and after intervention.Complications such as abdominal infection,gastrointestinal bleeding,anastomotic fistula,incision infection,hospitalization days,time to ambulation,time to anal exhaust and satisfaction rate of intervention were recorded to evaluate the intervention effect.Results Before intervention,there were no significant differences in TRF,PAB,ALB,IgA,IgG and IgM between two groups(all P>0.05).After intervention,the TRF,PAB,ALB,IgA,IgG and IgM in observation group were higher than those in control group(all P<0.05).During the intervention,the total incidence of postoperative complications,time to postoperative anal exhaust,time to ambulation and length of hospital stay in the observation group were lower than those in the control group,with statistical significance(all P<0.05).In addition,the total satisfaction rate of intervention in observation group(96.0%)was significantly higher than that in control group(80.0%)(all P<0.05).Conclusion Rapid rehabilitation nursing combined with probiotic nutrition therapy can effectively reduce the incidence of postoperative complications in patients with radical surgery for pancreatic cancer,maintain the nu

关 键 词：快速康复护理 益生菌 肠内营养 胰腺癌 临床效果 

分 类 号：R451[医药卫生—治疗学]