加味三仁汤治疗脾虚湿热兼肝郁型慢性非萎缩性胃炎临床观察  

Clinical efficacy of modified Sanren Decoction for chronic non-atrophic gastritis of spleen deficiency damp-heat and liver stagnation

作　　者：郭心怡 刘长兴 赵丹[1] 姚东 黄雅慧 GUO Xinyi;LIU Changxing;ZHAO Dan;YAO Dong;HUANG Yahui(2020 graduate student,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000;Department of Spleen and Stomach Diseases,Xi'an Hospital of Traditional Chinese Medicine,Xi'an,Shaanxi 710021)

机构地区：[1]陕西中医药大学,陕西咸阳712000 [2]陕西省西安市中医医院脾胃病科,陕西西安710021

出　　处：《河北中医》2023年第7期1097-1101,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：全国老中医药专家传承工作室建设项目(陕中医药函〔2022〕36号)。

摘　　要：目的观察加味三仁汤治疗脾虚湿热兼肝郁型慢性非萎缩性胃炎(CNAG)的临床疗效。方法将70例脾虚湿热兼肝郁型CNAG患者按照随机数字表法分为2组,治疗组35例予加味三仁汤治疗,对照组35例予枫蓼肠胃康分散片治疗。2组均治疗8周后统计疗效,比较2组中医症状(包括胃脘胀痛、胸胁窜痛、情志不畅、胃脘嘈杂、嗳气、反酸、口干口苦、大便黏滞稀溏不爽)评分、汉密尔顿焦虑量表(HAMA)评分及汉密尔顿抑郁量表(HAMD)评分变化情况,并观察2组治疗期间不良反应发生情况。结果治疗组总有效率94.29%(33/35),不良反应发生率11.43%(4/35),对照组总有效率77.14%(27/35),不良反应发生率17.14%(6/35),治疗组疗效优于对照组(P<0.05),且2组不良反应发生率比较差异无统计学意义(P>0.05)。与本组治疗前比较,2组治疗后中医症状胃脘胀痛、胸胁窜痛、情志不畅、胃脘嘈杂、嗳气、反酸、口干口苦、大便黏滞稀溏不爽及总分均降低(P<0.05),且治疗组治疗后各中医症状评分及总分均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后HAMA评分及HAMD评分均降低(P<0.05),且治疗组治疗后HAMA评分及HAMD评分均低于对照组(P<0.05)。结论加味三仁汤治疗脾虚湿热兼肝郁型CNAG患者临床疗效确切,可有效改善患者中医症状,缓解焦虑抑郁情绪,且安全性高,不会增加不良反应。Objective To observe the clinical efficacy of modified Sanren Decoction for chronic non-atrophic gastritis(CNAG)of spleen deficiency damp-heat and liver stagnation.Methods Totally 70 CNAG patients(spleen deficiency damp-heat and liver stagnation)were assigned to the treatment group(n=35)and the control group(n=35),in which they were treated with modified Sanren Decoction and Fengliao Changweikang Dispersible Tablets,respectively.Treated for 8 weeks,the aim was to compare traditional Chinese medicine(TCM)symptom(stomach pain,chest pain,poor mood,noisy,belching,acid reflux,dry mouth,stool sticky loose and uncomfortable)score,Hamilton Anxiety Scale(HAMA)scores,Hamilton Depression Scale(HAMD)scores.The curative effect and adverse reactions were assessed.Results After treatment,the overall effective rate in the treatment group was higher than that in the control group(94.29%[33/35]vs 77.14%[27/35],P<0.05).The difference was not statistically significant in the incidence of adverse reactions between the treatment group and the control group(11.43%[4/35]vs 17.14%[6/35],P>0.05).TCM symptom scores in the both groups were decreased(P<0.05),which decreased in the treatment group compared with the control group(P<0.05);HAMA and HAMD scores in groups were decreased(P<0.05),the reduction in the treatment group was more prevalent(P<0.05).Conclusion For CNAG patients(spleen deficiency damp-heat and liver stagnation),modified Sanren Decoction has definite curative effect,which can effectively improve TCM symptoms,relieve anxiety and depression,and it has high safety without increasing adverse reactions.

关 键 词：慢性非萎缩性胃炎 脾虚湿热 肝郁 三仁汤 中药疗法 

分 类 号：R289.6[医药卫生—方剂学]