丹参饮加味联合脱氧核苷酸钠注射液治疗对成人病毒性心肌炎气滞血瘀型心肌功能、氧化应激的影响  

Modified Danshen Decoction combined with sodium deoxynucleotide in the treatment of viral myocarditis of Qi stagnation blood stasis type and its effect on myocardial function and oxidative stress

作　　者：卢艳 张蕾 符大天 林捷[4] 符琼方[4] 杨树博 LU Yan;ZHANG Lei;FU Datian;LIN Jie;FU Qiongfang;YANG Shubo(Department of Pharmacy,Qionghai Hospital of Traditional Chinese Medicine,Qionghai,Hainan 571400;Department of Pharmacy,the First Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570102;Department of Pharmacy,Hainan Women and Children's Medical Center,Haikou,Hainan 570102;Department of Traditional Chinese Medicine,Haikou People's Hospital,Haikou,Hainan 570208;Department of Cardiology,the First Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570102)

机构地区：[1]海南省琼海市中医院药剂科,海南琼海571400 [2]海南医学院第一附属医院药剂科,海南海口570102 [3]海南省妇女儿童医学中心药剂科,海南海口570102 [4]海南省海口市人民医院中医科,海南海口570208 [5]海南医学院第一附属医院心内科,海南海口570102

出　　处：《河北中医》2023年第7期1111-1113,1119,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：海南省自然科学基金面上项目(编号:820MS162)。

摘　　要：目的观察丹参饮加味联合脱氧核苷酸钠注射液治疗成人病毒性心肌炎(VMC)气滞血瘀型的疗效及对患者心肌功能、氧化应激的影响。方法将126例成人VMC气滞血瘀型患者按照随机数字表法分为3组,常规组42例予西医常规治疗,对照组42例在西医常规治疗基础上加用脱氧核苷酸钠注射液治疗,联合组42例在对照组治疗基础上联合丹参饮加味治疗。3组均治疗30天后统计疗效,比较3组治疗前后心肌功能指标心肌肌钙蛋白Ⅰ(cTnⅠ)及心肌肌钙蛋白T(cTnT)水平变化情况,比较3组治疗前后氧化应激指标一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽转移酶(GST)及丙二醛(MDA)水平变化情况。结果联合组总有效率95.24%(40/42),对照组总有效率80.95%(34/42),常规组总有效率59.52%(25/42),联合组总有效率高于对照组及常规组(P<0.05),对照组总有效率高于常规组(P<0.05)。与本组治疗前比较,3组治疗后心肌功能指标cTnⅠ及cTnT水平均降低(P<0.05),且联合组治疗后cTnⅠ及cTnT水平均低于对照组及常规组(P<0.05),对照组治疗后cTnⅠ及cTnT水平均低于常规组(P<0.05)。与本组治疗前比较,2组治疗后氧化应激指标NO及MDA水平均降低(P<0.05),SOD及GST水平均升高(P<0.05),且联合组治疗后NO、SOD、GST及MDA水平改善优于对照组及常规组(P<0.05),对照组治疗后NO、SOD、GST及MDA水平改善优于常规组(P<0.05)。结论丹参饮加味联合脱氧核苷酸钠注射液治疗成人VMC气滞血瘀型临床疗效确切,可有效提高患者心肌功能,调节氧化应激平衡,缓解氧化应激损伤,疗效显著,安全可靠。Objective To study the effect of modified Danshen Decoction combined with sodium deoxynucleotide on viral myocarditis(VMC)of Qi stagnation blood stasis type and its effect on myocardial function and oxidative stress.Methods One hundred twenty-six VMC patients(Qi stagnation blood stasis type)were radomly assigned in 1:1:1 ratio to three groups:the conventional group(conventional western medicine),the control group(conventional western medicine+sodium deoxyribonucleotide injection),the combined group(conventional western medicine+sodium deoxyribonucleotide injection+modified Danshen Decoction).The curative effect was counted after 30 days of treatment.The key observation was the changes of myocardial function indexes(cardiac troponin I[cTnI]and cardiac troponin T[cTnT]),oxidative stress indexes(nitric oxide[NO],superoxide dismutase[SOD],glutathione transferase[GST],and malondialdehyde[MDA])before and after treatment were compared between groups.Results The total effective rate in the combined group,the control group,and the conventional group was 95.24%(40/42),80.95%(34/42),and 59.52%(25/42),respectively,which was significantly higher in the combined group than in the control group and the routine group(P<0.05),and the control group was significantly higher than the routine group(P<0.05).After treatment,the levels of myocardial function indexes(cTnI and cTnT)in the three groups decreased(P<0.05),and which in the treatment group were lower than those in the other groups(P<0.05),and the control group were lower than those in the routine group(P<0.05).After treatment,decreased NO and MDA,and increased SOD and GST in groups were detected(P<0.05),the treatment group was superior to the control group and the routine group for NO,SOD,GST and MDA(P<0.05),and and the control group were superior to the routine group(P<0.05).Conclusion For VMC patients(Qi stagnation blood stasis type),modified Danshen Decoction combined with sodium deoxynucleotide shows a definite clinical curative effect.It can effectively enhance myocardial

关 键 词：病毒性心肌炎 心肌功能 氧化应激 中西医结合 

分 类 号：R542.2[医药卫生—心血管疾病]