二甲双胍、胰岛素与美托洛尔治疗糖尿病合并冠心病的疗效评价  

Efficacy of Metformin,Insulin and Metoprolol in Treating Diabetic Patients with Coronary Heart Disease

作　　者：孙军鸽 高琴 王世喜 SUN Junge;GAO Qin;WANG Shixi(Department of Cardiovascular Medicine,Shandong Guoxin Yiyang Health Care Group Zaozhuang Central Hospital,Zaozhuang,Shandong Province,277606 China)

机构地区：[1]山东国欣颐养集团枣庄中心医院心血管内科,山东枣庄277606

出　　处：《糖尿病新世界》2023年第10期70-72,99,共4页Diabetes New World Magazine

摘　　要：目的分析二甲双胍、胰岛素与美托洛尔治疗糖尿病合并冠心病的疗效。方法选取2020年1月—2022年1月山东健康集团枣庄中心医院收治的70例糖尿病合并冠心病患者为研究对象,随机抽签分为两组,各35例,均施行高剂量美托洛尔治疗,观察组在此基础上行胰岛素治疗,对照组行二甲双胍治疗,观察其治疗效果。结果观察组的治疗有效率94.29%高于对照组的77.14%,差异有统计学意义(P<0.05)。治疗前,两组血糖指标比较,差异无统计学意义(P>0.05),治疗后,观察组的空腹血糖、餐后2 h血糖及糖化血红蛋白均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血脂指标比较,差异无统计学意义(P>0.05),治疗后,观察组TC、TG及LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。结论胰岛素与高剂量美托洛尔治疗糖尿病合并冠心病的疗效优于联合二甲双胍,其治疗有效率更高,对血糖及血脂指标的改善作用比较明显。Objective To analyze the efficacy of metformin,insulin and metoprolol in treating diabetic patients with coronary heart disease.Methods Seventy patients with diabetes complicated with coronary heart disease who were admitted to Zaozhuang Central Hospital of Shandong Health Group from January 2020 to January 2022 were selected as the research objects.They were randomly divided into two groups,35 patients in each group,who were treated with high-dose Metoprolol.On this basis,the observation group received insulin treatment,and the control group received Metformin treatment to observe its therapeutic effect.Results The effective rate of treatment in the observation group was 94.29%higher than that in the control group,which was 77.14%,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood glucose indicators between the two groups(P>0.05).After treatment,the fasting blood glucose,blood glucose 2 hours after meal and Glycated hemoglobin in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood lipid indicators between the two groups(P>0.05).After treatment,the levels of TC,TG,and LDL-C in the observation group were lower than those in the control group,while the levels of HDL-C were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion The efficacy of insulin and high-dose Metoprolol in the treatment of diabetes with coronary heart disease is better than that of combination of Metformin,with a higher therapeutic efficiency and obvious improvement of blood glucose and lipid indicators.

关 键 词：美托洛尔 糖尿病 冠心病 血糖指标 血脂指标 治疗效果 

分 类 号：R4[医药卫生—临床医学]