注射用顺苯磺酸阿曲库铵对全身麻醉手术患者应激反应和围拔管期残余肌松效应的影响  

Effects of Atracurium Cisneneneba Benzenesulfonate for Injection on Stress Response and Residual Muscle Relaxation in Patients Undergoing General Anesthesia Surgery

作　　者：张艳红 齐芬 范丽梅 刘朝岭 ZHANG Yanhong;QI Fen;FAN Limei;LIU Chaoling(Department of Anesthesiology,People's Hospital of Jinxiang County,Shandong 272200)

机构地区：[1]山东省金乡县人民医院麻醉科,山东金乡272200

出　　处：《中国医药指南》2023年第19期97-99,共3页Guide of China Medicine

摘　　要：目的探究注射用顺苯磺酸阿曲库铵对全身麻醉手术患者应激反应和围拔管期残余肌松效应的影响。方法选择我院2020年5月至2021年5月期间接诊的102例全身麻醉手术患者开展研究,按照随机抽签法进行分组,对照组51例、观察组51例。均进行丙泊酚与枸橼酸舒芬太尼注射液麻醉诱导,其中对照组予以罗库溴铵注射液持续静脉泵注以维持术中麻醉,观察组予以注射用顺苯磺酸阿曲库铵注射液持续静脉泵注以维持术中麻醉,对比插管条件优良率,以及不同时间点血流动力学变化[心率(HR)、平均动脉压(MAP)]、围拔管期肌松恢复指数。结果①插管条件优良率比较结果:观察组插管条件优良率(96.08%)较对照组(80.39%)高,比较差异显著(P<0.05)。②血流动力学指标比较结果:观察组切皮时(T1)、拔管时(T2)时MAP、HR较对照组低(P<0.05)。③围拔管期残余肌松效应比较结果:观察组围拔管期残余肌松效应持续时间、拔管肌松恢复时间较对照组短(P<0.05)。结论在全身麻醉手术中注射用顺苯磺酸阿曲库铵的肌松效应较理想,可提高插管条件优良率,对血流动力学变化影响小,减少围拔管期残余肌松效应,促进患者术后恢复进程。Objective To explore the effect of atracurium cisneneneba benzenesulfonate for injection on stress response and residual muscle relaxation in patients undergoing general anesthesia surgery.Methods A study was conducted on 102 patients undergoing general anesthesia surgery who were admitted to our hospital from May 2020 to May 2021.They were randomly divided into the control group of 51 patients and the observation group of 51 patients.Was induced with propofol and sufentanil citrate injection.The control group was given continuous intravenous infusion of rocuronium bromide injection to maintain intraoperative anesthesia,and the observation group was given continuous intravenous infusion of cisatracurium besylate injection to maintain intraoperative anesthesia.The excellent rate of intubation conditions,as well as hemodynamic changes at different time points[heart rate(HR),mean arterial pressure(MAP)],and muscle relaxation recovery index during extubation were compared.Results(1)Good conditions of intubation:the excellent rate of intubation conditions in observation group was 96.08%higher than that in control group 80.39%,and the difference was significant(P<0.05).(2)In terms of hemodynamics:MAP and HR in the observation group were lower than those in the control group during skin incision(T1)and extubation(T2)(P<0.05).(3)Residual muscle release effect during periextubation:the duration of residual muscle release effect and recovery time of extubation muscle release during periextubation in observation group were shorter than those in control group(P<0.05).Conclusion The muscle relaxant effect of atracurium cisneneneba benzenesulfonate injection combined with propofol during general anesthesia surgery is ideal,which can improve the excellent rate of intubation conditions,have little impact on hemodynamic changes,reduce the residual muscle relaxant effect during the peri extubation period,and promote the postoperative recovery process of patients.

关 键 词：全身麻醉 丙泊酚 注射用顺苯磺酸阿曲库铵 应激反应 残余肌松效应 

分 类 号：R614.2[医药卫生—麻醉学]