UDCA,a novel strategy for preventing SARS-CoV-2 infection via FXR-mediated ACE2 downregulation  

作　　者：Mengjiao Chen Rongrong Zhu Min Zhang 

机构地区：[1]Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Department of Bioinformatics and Medical Big Data,Hengyang Medical School,University of South China,Hengyang 421001,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第5期885-887,共3页生物化学与生物物理学报（英文版）

基　　金：supported by the grant from the Research Foundation of Education Bureau of Hunan Province,China(No.19B490).

摘　　要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in the current outbreak of coronavirus disease 2019(COVID-19)in humans,causing worldwide health issues[1].The periodic and unexpected consequences have made SARS-CoV-2 a severe threat to human beings,forcing researchers to explore the underlying mechanisms of infection.Angiotensin converting enzyme 2(ACE2),a cell surface protein,acts as a specific functional receptor for SARS-CoV-2,as well as the earlier SARS-CoV.

关 键 词：ACE2 UDCA ACUTE 

分 类 号：R563.1[医药卫生—呼吸系统]