髓源性抑制细胞在乙型肝炎病毒感染中的研究进展  

Advances on myeloid-derived suppressor cells in hepatitis B virus infection

作　　者：王诗芬 姚妮 吕燕 赵毓宏 崔大伟[1] 谢珏[1] Wang Shifen;Yao Ni;Lyu Yan;Zhao Yuhong;Cui Dawei;Xie Jue(Department of Blood Transfusion,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院输血科,杭州310003

出　　处：《中华临床感染病杂志》2023年第3期234-240,共7页Chinese Journal of Clinical Infectious Diseases

基　　金：国家自然科学基金(82172335、81971994、81871709、91846103);浙江省重点研发计划项目(2020C03032)。

摘　　要：髓源性抑制细胞(Myeloid-derived suppressor cells,MDSCs)是一类处于未分化成熟状态的异质性细胞群体,能够抑制T淋巴细胞功能。在肿瘤、感染和慢性炎症等病理情况下,MDSCs大量扩增,参与免疫逃逸、免疫耐受和炎性反应等过程。MDSCs在乙型肝炎病毒(Hepatitis C virus,HBV)感染引起的病理机制中发挥重要作用,但关于HBV感染中MDSCs激活、分化和功能机制等仍不清楚。本文就MDSCs的特性、在HBV感染中的作用和功能以及相关的药物治疗进行阐述,为后续的机制研究和靶向治疗提供思路。Myeloid-derived suppressor cells(MDSCs)are a group of immature and heterogeneous cells that can inhibit T cell function.In pathological conditions such as tumors,infections,and chronic inflammation,the large expansion of MDSCs is involved in processes of immune escape,immune tolerance and inflammatory reactions.MDSCs are also crucial in the pathophysiology of hepatitis B virus(HBV)infection,however,their activation,differentiation,and function during HBV infection are still unclear.This article reviews the general characteristics and roles of MDSCs in HBV infection,as well as related drug therapies,in order to provide information for further research on the related mechanism and potential targeted treatment.

关 键 词：髓源性抑制细胞 乙型肝炎病毒 慢性乙型肝炎 终末期肝病 

分 类 号：R512.62[医药卫生—内科学]