慢性心力衰竭患者血清内皮细胞特异性分子1和斯钙素1表达水平及心功能相关性研究  

Correlation between serum Esm1 and Stc1 expression levels and cardiac function in patients with chronic heart failure

作　　者：李卫娜[1] 王猛[1] 刘瑞娟[1] 张振[1] LI Wei-na;WANG Meng;LIU Rui-juan;ZHANG Zhen(Department of Cardiovascular Medicine,Zhuozhou City Hospital,Baoding 072750,China)

机构地区：[1]涿州市医院心血管内科,河北省保定市072750

出　　处：《中国心血管病研究》2023年第7期632-637,共6页Chinese Journal of Cardiovascular Research

基　　金：保定市市级科技计划项目(2241ZF146)。

摘　　要：目的探究慢性心力衰竭(CHF)患者血清内皮细胞特异性分子1(Esm1)和斯钙素1(Stc1)表达水平与心功能的相关性。方法收集涿州市医院2020年1月至2022年1月收治的120例CHF患者作为研究对象,设为研究组。根据美国纽约心脏病协会(NYHA)分级标准,将CHF患者分为心功能Ⅱ级组39例、Ⅲ级组45例、Ⅳ级组36例;同期选择76名健康体检者作为对照组。比较两组研究对象的一般临床资料。采用酶联免疫吸附实验(ELISA)检测研究对象血清Esm1、Stc1水平并进行比较;采用Pearson相关分析法分析血清Esm1、Stc1水平与心功能指标的相关性。多因素logistic回归分析探究CHF的影响因素。采用受试者工作特征(ROC)曲线分析血清Esm1、Stc1水平对CHF的诊断价值。结果与对照组相比,CHF组血清Esm1、Stc1水平、LVEDD显著升高(P<0.05),LVEF显著下降(P<0.05)。与Ⅱ级组相比,Ⅲ、Ⅳ级组的血清Esm1、Stc1水平、LVEDD显著升高(P<0.05),LVEF显著下降(P<0.05)。与Ⅲ级组相比,Ⅳ级组的血清Esm1、Stc1水平、LVEDD显著升高(P<0.05),LVEF显著下降(P<0.05)。Pearson相关分析显示,CHF患者血清Esm1、Stc1水平与LVEDD呈正相关(r=0.588,r=0.425,P<0.05);与LVEF呈负相关(r=-0.235,r=-0.498,P<0.05)。多因素logistic回归分析显示,血清Esm1、Stc1水平是患者发生CHF的危险因素(P<0.05)。二者联合诊断CHF的曲线下面积(AUC)为0.936,灵敏度为85.00%,优于Esm1、Stc1单独检测的AUC和灵敏度(AUC分别为0.868、0.842;灵敏度分别为77.50%、62.83%)(P<0.05)。结论CHF患者血清Esm1、Stc1水平升高,二者均与心功能相关,可作为评估CHF患者心功能的潜在标志物。Objective To explore the correlation between the expression levels of serum endothelial cell specific molecule 1(Esm1)and stanniocalcin 1(Stc1)and cardiac function in patients with chronic heart failure(CHF).Methods A total of 120 CHF patients admitted to our hospital from January 2020 to January 2022 were collected as the research objects and set as the research group.According to the American New York Heart Association(NYHA)classification standard,the CHF patients were grouped into the cardiac function classⅡgroup with 39 cases,classⅢgroup with 45 cases,and classⅣgroup with 36 cases;76 healthy subjects were included as the control group as the same time.The general clinical data of the two groups were compared.The serum Esm1 and Stc1 levels of the research subjects were detected by enzyme-linked immunosorbent assay(ELISA)and compared.Pearson correlation analysis was used to analyze the correlation between serum Esm1 and Stc1 levels and cardiac function indexes.Multi-factor logistic regression analysis was used to explore the influencing factors of CHF.The diagnostic value of serum Esm1 and Stc1 levels for CHF was analyzed by the ROC curve.Results Compared with the control group,the serum levels of Esm1,Stc1 and LVEDD in the CHF group were obviously increased(P<0.05);and the LVEF was obviously decreased(P<0.05).Compared with the gradeⅡgroup,the levels of serum Esm1,Stc1 and LVEDD in the gradeⅢandⅣgroups were obviously increased(P<0.05),and LVEF was obviously decreased(P<0.05).Compared with the gradeⅢgroup,the levels of serum Esm1,Stc1 and LVEDD in the gradeⅣgroup were obviously increased(P<0.05),and the LVEF was obviously decreased(P<0.05).The results of Pearson correlation analysis showed that serum Esm1 and Stc1 levels in CHF patients were positively correlated with LVEDD(r=0.588,r=0.425,P<0.05),and negatively correlated with LVEF(r=-0.235,r=-0.498,P<0.05).Multivariate logistic regression analysis showed that serum levels of Esm1 and Stc1 were he risk factors for CHF in the patients(P<0.05).The

关 键 词：慢性心力衰竭 内皮细胞特异性分子1 斯钙素1 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]