2023版鼻腔盐水冲洗防治新型冠状病毒感染的临床指引  

Clinical guidelines for nasal saline irrigation for the prevention and treatment of SARS-CoV-2 infection(2023 edition)

作　　者：余少卿[1] 杨玉成[2] 许元腾[3] 孟娟[4] 金玲[1] 娄鸿飞 孙娜 徐睿[7] 叶菁[8] 王天生[9] 刘锋[4] 石照辉 谢志海[11] 孟粹达[12] 叶惠平 喻国冻 李健[7] 王英[15] 许成利 魏欣[17] 左可军[7] 杨艳莉 姜彦[19] 巴罗[20] 陆美萍[21] 唐隽[22] 安云芳[23] 许昱[24] 杨贵 曾明[26] 王向东[27] 孙悦奇[28] 杨钦泰[29] 刘文龙 张天虹[31] 洪海裕[32] 雍军[33] 孙亚男[34] 邱前辉[35] 陈建军[36] 谭国林[9] 王洪田 张维天[38] 李华斌 中国鼻病研究协作组 YU Shaoqing;YANG Yucheng;XU Yuanteng;MENG Juan;JIN Ling;LOU Hongfei;SUN Na;XU Rui;YE Jing;WANG Tiansheng;LIU Feng;SHI Zhaohui;XIE Zhihai;MENG Cuida;YE Huiping;YU Guodong;LI Jian;WANG Ying;XU Chengli;WEI Xin;ZUO Kejun;YANG Yanli;JIANG Yan;BA Luo;LU Meiping;TANG Juan;AN Yunfang;XU Yi;YANG Gui;ZENG Ming;WANG Xiangdong;SUN Yueqi;YANG Qintai;LIU Wenlong;ZHANG Tianhong;HONG Haiyu;YONG Jun;SUN Yanan;QIU Qianhui;CHEN Jianjun;TAN Guolin;WANG Hongtian;ZHANG Weitian;LI Huabin;Chinese Rhinology Research Collaboration Group.(Department of Otolaryngology Head and Neck Surgery,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China;Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Otolaryngology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350004,China;Department of Otolaryngology Head and Neck Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Otolaryngology,Eye&ENT Hospital,Fudan University,Shanghai 200031,China;Department of Otolaryngology Head and Neck Surgery,Huadong Hospital,Fudan University,Shanghai 200040,China;Otorhinolaryngology Hospital,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Otolaryngology Head and Neck Surgery,Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Otolaryngology,Longgang E.N.T Hospital&Shenzhen Key Laboratory of E.N.T,Institute of E.N.T,Shenzhen 518172,China;Department of Otolaryngology Head and Neck Surgery,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Otolaryngology Head and Neck Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Department of Otolaryngology,Guizhou Provincial Hospital,Guiyang 550002,China;Department of Otolaryngology,Affiliated Hospital of Guizhou M

机构地区：[1]同济大学附属同济医院耳鼻咽喉头颈外科兼变态反应(过敏)科,上海200065 [2]重庆医科大学附属第一医院耳鼻咽喉头颈外科,重庆400016 [3]福建医科大学附属第一医院耳鼻咽喉科,福州350004 [4]四川大学华西医院耳鼻咽喉头颈外科,成都610041 [5]复旦大学附属眼耳鼻喉科医院耳鼻喉科,上海200031 [6]复旦大学附属华东医院耳鼻咽喉头颈外科,上海200040 [7]中山大学附属第一医院耳鼻咽喉科医院耳鼻喉科,广州510080 [8]南昌大学第一附属医院耳鼻咽喉头颈外科,南昌330006 [9]中南大学湘雅三医院耳鼻咽喉头颈外科,长沙410013 [10]深圳市耳鼻咽喉研究所/深圳市龙岗区耳鼻咽喉医院耳鼻咽喉头颈外科,深圳518172 [11]中南大学湘雅医院耳鼻咽喉头颈外科,长沙410008 [12]吉林大学中日联谊医院耳鼻咽喉头颈外科,长春130033 [13]贵州省人民医院耳鼻咽喉科,贵阳550002 [14]贵州医科大学附属医院耳鼻咽喉头颈外科,贵阳550004 [15]郑州大学第一附属医院鼻科,郑州450052 [16]广西医科大学第二附属医院耳鼻咽喉头颈外科,南宁530007 [17]海南省人民医院/海南医学院附属海南医院耳鼻咽喉头颈外科,海口570311 [18]昆明医科大学第一附属医院耳鼻喉一科,昆明650032 [19]青岛大学附属医院耳鼻咽喉头颈外科,青岛266003 [20]西藏自治区人民医院耳鼻咽喉科,拉萨850000 [21]南京医科大学第一附属医院耳鼻喉科,南京210029 [22]佛山市第一人民医院耳鼻咽喉头颈外科,佛山528000 [23]山西医科大学第二医院耳鼻喉科,太原030001 [24]武汉大学人民医院耳鼻咽喉头颈外科,武汉430060 [25]深圳市龙岗区中心医院耳鼻喉科,深圳518116 [26]华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科,武汉430030 [27]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [28]中山大学附属第七医院耳鼻咽喉科,深圳518107 [29]中山大学附属第

出　　处：《中国眼耳鼻喉科杂志》2023年第4期267-273,共7页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：科技部国家重点研发计划(2022YFC2504100);国家自然科学基金杰出青年基金(81725004),国家自然科学基金(81670901、81873689、81873690、81870700、82071014、82171104、82171120、82260219);上海市科委优秀学科带头人项目(19XD4010000);上海市耳鼻咽喉疾病临床中心重大专项(20MC920200);上海市科委项目(20MC920200、19XD4010000);上海市促进市级医院临床技能与临床创新能力三年行动计划项目(SHDC2020CR4090);上海卫生健康委员会临床研究项目(202140293)。

摘　　要：新型冠状病毒(如奥密克戎亚型)感染患者的临床潜伏期似乎越来越短,传染性越来越强,症状主要发生在上呼吸道。因此,现阶段,以鼻腔为代表的上呼吸道病毒感染的预防与治疗已成为防控重点。除了规范佩戴口罩外,鼻腔盐水冲洗可作为常用的鼻腔局部护理或治疗方法,能预防病毒感染或减少病毒感染概率并降低鼻腔病毒载量,缩短感染后康复时间,成本低且副作用小,可作为防治新型冠状病毒感染的经济、有效手段。在2022版《鼻腔盐水冲洗预防新型冠状病毒感染专家共识》的基础上,中国鼻病研究协作组的中青年鼻科专家,结合新型冠状病毒亚型的致病特征,参考国内外循证医学证据,总结当下疫情防控的临床经验,制订了《2023版鼻腔盐水冲洗防治新型冠状病毒感染的临床指引》,以期更快速有效地指导临床防治。The clinical incubation period of patients infected with SARS-CoV-2(such as Omicron subtype)seems to be getting shorter and more contagious,with symptoms mainly occurring in the upper respiratory tract.Therefore,at present,the prevention and treatment of upper respiratory virus infection represented by nasal cavity has become the focus of prevention and control.In addition to wearing face mask properly,nasal saline irrigation is suggested as a low cost nasal physical therapy with advantage to reduce viral infection and accelerate the recovery of inflammation with less side effects.It has become one of the economic and effective means to prevent and control SARS-CoV-2 infection.Based on the 2022 Expert consensus on nasal saline irrigation for the prevention of SARS-CoV-2 infection,young and middle-aged rhinologists in the Chinese Rhinology Research Collaboration Group referred to the pathogenic characteristics of SARSCoV-2 subtypes and evidence-based medical evidence at home and abroad,summarized the clinical experience of epidemic prevention and control,and formulated the Clinical guideline for nasal saline irrigation for the prevention and treatment of SARS-CoV-2 infection(2023 edition),in order to guide clinical prevention and treatment more quickly and effectively.

关 键 词：新型冠状病毒 鼻腔感染 鼻腔盐水冲洗 防治 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]