Synthesis of chiral pyridine-oxazolines via a catalytic asymmetric Heine reaction of meso-N-(2-picolinoyl)-aziridines  

作　　者：Yi Li Wang-Yuren Li Xiaoxue Tang Xiaohua Liu Xiaoming Feng 

机构地区：[1]Key Laboratory of Green Chemistry&Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1531-1535,共5页有机化学前沿（英文）

基　　金：We appreciate the National Natural Science Foundation of China(21890723 and 21921002)for financial support.

摘　　要：An asymmetric Heine reaction of (meso)-N-(2-picolinoyl)-aziridines catalyzed by a chiral ytterbium(III)–N,N′-dioxide complex was established. A novel library of pyridine-oxazolines was obtained with decent yields and enantioselectivities, which show potential as chiral ligands and Lewis base catalysts. Besides, based on the control experiments, a possible work mode was proposed.

关 键 词：chiral ASYMMETRIC PYRIDINE 

分 类 号：O62[理学—有机化学]