Transition-metal-free synthesis of 4-aminoisoquinolin-1(2H)-ones via a tandem reactionof arynes and oxazoles  

作　　者：Shaojun Liu Pei Xie Leifang Wu Jixing Zhao Zhihua Cai Lin He 

机构地区：[1]Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,School of Chemistry and Chemical Engineering,Shihezi University,Xinjiang Uygur Autonomous Region 832000,People’s Republic of China [2]Analysis and Testing Center of Shihezi University,Xinjiang Uygur Autonomous Region,832000,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1550-1555,共6页有机化学前沿（英文）

基　　金：supported by the National Natural Science Foundation of China(No.22161039);the Excellent Young Teachers Plan of Bingtuan(2017CB001 and CZ027203,CZ002203);the International Cooperation Project of Shihezi University(No.GJHZ201801).

摘　　要：A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aromatization/tautamerization process to produce 4-amino isoquinolin-1(2H)-ones in moderate to excellent yields. The reaction can be easily scaled up and the product can be transformed to isoquinoline derivatives efficiently.

关 键 词：synthesis TRANSITION 

分 类 号：O62[理学—有机化学]