Synthesis and application of novel P-chiralmonophosphorus ligands  

作　　者：Xiaoxiao Xie Sanliang Li Qiaoyu Chen Hao Guo Junfeng Yang Junliang Zhang 

机构地区：[1]Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai,200438,China [2]Academy for Engineering and Technology,Fudan University,Shanghai,200438,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1589-1592,共4页有机化学前沿（英文）

基　　金：funding support of the NSFC(22031004,21921003,and 21901043),STCSM(21ZR1445900);Shanghai Municipal Education Commission(20212308).

摘　　要：A series of novel P-stereogenic monophosphorus ligands (Xie-phos) were synthesized via the hydrophosphinylation of alkynes with secondary phosphine oxides by palladium catalysis and the following basemediated cyclization. They are easily synthesized and modified. Their utility was demonstrated in catalyticasymmetric reactions, including α-arylation of amides and the domino Heck/Suzuki reaction with moderate enantioselectivity.

关 键 词：PHOSPHORUS PALLADIUM CHIRAL 

分 类 号：O62[理学—有机化学]