基于数据挖掘的中药复方治疗血瘀型血管性痴呆用药规律研究  

Study on medication law of TCM compounds for treatment of blood stasis type vascular dementia

作　　者：宗子婴 署文杰 孙西庆[2] Zong Ziying;Shu Wenjie;Sun Xiqing(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Introneurosis,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,济南250014 [2]山东中医药大学附属医院神经内一科,济南250014

出　　处：《国际中医中药杂志》2023年第7期892-897,共6页International Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技项目(2020Q011)。

摘　　要：目的运用数据挖掘方法分析中药复方治疗血瘀型血管性痴呆(VD)的核心药组及用药规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)2000年1月-2021年11月有关中药治疗血瘀型VD的文献,采用Microsoft Office Excel 2019、SPSS Modeler 18.0、SPSS Statistics 25.0、R x644.1.2、Origin 2021等软件对数据进行用药频次分析、中药性味归经分析、关联规则、聚类分析、因子分析及数据可视化。结果共纳入文献196篇,得到处方196首,涉及中药200味。高频用药为石菖蒲、川芎、丹参、远志、红花,用药药性以温、平、寒为主,药味以甘、苦、辛为主,归经以肝、脾、心经为主。关联规则分析共得到2味药物关联规则19个,具代表性的规则有石菖蒲-远志、川芎-红花、石菖蒲-郁金等,聚类分析共提取得到4类,因子分析共提取8个公因子。结论血瘀型VD的核心病机为瘀血阻滞脑络,兼有气虚、阴虚、痰浊等病理因素,中药复方治疗本病以活血化瘀为基本治法,临证依患者兼症的不同,选用不同的活血方法和活血药物,分别施以健脾化痰、滋阴养血、开窍醒神、补肾健脾、行气搜络等佐治之法。Objective To explore the medication law and core Traditional Chinese Medicine(TCM)compounds in the treatment of blood stasis vascular dementia(VD)based on data mining.Methods The literature about TCM treatment for blood stasis VD was retrieved from the databases of CNKI,Wanfang,VIP,and CBM from January 2000 to November 2021.Microsoft Office Excel 2019,SPSS Modeler 18.0,SPSS Statistics 25.0,R X644.1.2,and Origin 2021 were used to perform medication frequency analysis,frequency analysis of four properties and five tastes of TCM,association rules,clustering analysis,factor analysis and data visualization.Results A total of 196 articles were included,with 196 TCM prescriptions,involving 200 kinds of Chinese materia medica.High-frequency drugs were for Acori Tatarinowii Rhizoma,Chuanxiong Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Polygalae Radix,Carthami Flos.The medicinal properties were mainly warm,mild and cold,the tastes were mainly sweet,bitter and pungent,and the meridians were mainly liver meridian,spleen meridian and heart meridian.A total of 19 association rules were obtained from the analysis of association rules for 2 kinds of Chinese materia medica,and the rules of the representative were Acori Tatarinowii Rhizoma-Polygalae Radix,Chuanxiong Rhizoma-Carthami Flos,Acori Tatarinowii Rhizoma-Curcumae Radix.A total of 4 categories were extracted through clustering analysis.Factor analysis extracted a total of 8 common factors.Conclusion The core pathogenesis of blood stasis VD is blood stasis blocking brain collaterals,and there were also pathological factors such as qi deficiency,yin deficiency,phlegm turbidity and so on.The basic treatment is promoting blood circulation and removing stasis,and different methods of promoting blood circulation and drugs are selected.The methods of strengthening spleen and reducing phlegm,nourishing yin and blood,inducing resuscitation,tonifying the kidney and spleen,regulating qi,promoting collaterals and so on can also be used based on syndromes and symptoms of the patien

关 键 词：痴呆 血管性 血瘀 中医药 数据挖掘 关联规则 聚类分析 因子分析 用药规律 

分 类 号：R277.7[医药卫生—中医学]