中药干预人肺腺癌A549细胞抗肿瘤作用机制研究进展  

Research progress in the mechanism of TCM intervention in anti-tumor effect of A549 cells in human lung adenocarcinoma

作　　者：张超越 肖军 龙麟 孙金芳 Zhang Chaoyue;Xiao Jun;Long Lin;Sun Jinfang(the First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Cancer Center of Qingdao Hospital of Traditional Chinese Medicine,Qingdao Hiser Hospital,Qingdao 266033,China;Hematology Department of West Branch of Qingdao Hospital of Traditional Chinese Medicine,Qingdao Hiser Hospital,Qingdao 266002,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250355 [2]青岛市中医医院市海慈医院肿瘤中心,青岛266033 [3]青岛市中医医院市海慈医院西院区血液科,青岛266002

出　　处：《国际中医中药杂志》2023年第7期921-925,共5页International Journal of Traditional Chinese Medicine

基　　金：海藻活性物质国家重点实验室开放基金项目(SKL-BASS1805);2020年度山东省中医药科技项目(2020Z31,2020Q075);青岛市2021年度医药卫生科研计划项目(2021-WJZD034)。

摘　　要：中药通过干预人肺腺癌A549细胞发挥抗肿瘤作用,主要包括通过影响PI3K/Akt等通路激活或抑制下游靶蛋白Bcl-2、Bax或形成RIP1/RIP3/MLKL复合小体,从而诱导肺腺癌A549细胞凋亡;使细胞生长期阻滞,从而抑制肺腺癌A549细胞增殖;通过影响MMPs通路、STAT3通路和调控上皮间充质转化相关因子,从而抑制A549细胞侵袭和转移;抑制或激活相关蛋白表达或影响相关信号通路,从而逆转肺癌A549/DDP细胞株对顺铂和紫杉醇的耐药性。Traditional Chinese Medicine(TCM)exerts anti-tumor effects by intervening in A549 cells of human lung adenocarcinoma,mainly including activating or inhibiting downstream target proteins of Bcl-2 and Bax,or forming RIP1/RIP3/MLKL complex bodies by affecting pathways such as PI3K/Akt,thereby inducing apoptosis in A549 cells of lung adenocarcinoma;blocks the cell growth phase,thereby inhibiting the proliferation of lung adenocarcinoma A549 cells;inhibits invasion and metastasis of A549 cells by affecting the MMPs pathway,STAT3 pathway,and regulating epithelial mesenchymal transition related factors;suppresses or activates the expression of related proteins or affect related signaling pathways,thereby reversing the resistance of lung cancer A549/DDP cell lines to cisplatin and paclitaxel.

关 键 词：肺腺癌 A549细胞 中药 作用机制 综述 

分 类 号：R285[医药卫生—中药学]