异功散抗炎机制研究进展  

Study Progress on Anti-inflammatory Mechanism of Yigong Powder(异功散)

作　　者：夏黎 罗梅宏 XIA Li;LUO Meihong(Shanghai Baoshan District Hospital of Integrated Chinese and Western Medicine/Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201999,China)

机构地区：[1]上海市宝山区中西医结合医院/上海中医药大学附属宝山医院,上海201999

出　　处：《山东中医杂志》2023年第8期898-904,共7页Shandong Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(编号:81774271);国家自然科学基金青年基金项目(编号:81804021,8210151701);上海市2020年度“科技创新行动计划”医学创新研究项目(编号:20Y21900400);上海中医药大学预算内项目(编号:2019LK100);上海市宝山区科技创新专项基金项目(编号:19-E-4);上海市宝山区中西医结合医院国家自然基金培育专项(编号:GZRPYJJ-201802)。

摘　　要：异功散具有抗炎作用,对多种炎症因子的分泌有调控作用。综述了异功散全方及各组成药物主要活性成分的抗炎作用及机制,包括人参皂苷(Re、Rb1、Rb2、Rg1、Rg3、Rg5等)、白术内酯、茯苓酸、异甘草苷、橙皮苷、川陈皮素等。发现异功散主要通过调控炎症相关信号通路核因子(NF-κB)和丝裂原活化蛋白激酶(MAPK)以及抗氧化作用抑制促炎症因子的分泌,在多种炎症性疾病动物或细胞模型中得到验证。结合团队的研究成果,该方剂有用于预防和治疗炎症性疾病的药理基础,特别是用于慢性病贫血即炎症性贫血的治疗,值得进一步研究。参考文献57篇。Yigong Powder(异功散)with the effect of anti-inflammation could regulate secretion of a variety of inflammatory factors.In this paper,the anti-inflammatory effect and mechanism of the main active components of Yigong Powder including ginsenosides(Re,Rb1,Rb2,Rg1,Rg3,Rg5,etc.),atractylodes lactone,poria acid,isoglycyrrhizin,hemperidin,citriletin,etc.,were reviewed.In conclusion,Yigong Powder mainly regulates the secretion of inflammatory factors by regulating the inflammation-related signaling pathways,nuclear factorκ-B(NF-κB)and mitogen-activated protein kinases(MAPK)and its antioxidant effect,which has been verified in various inflammatory model of animal or cell.Combined with the research results by supervisor’s team,we hold that this formula could be used for the prevention and treatment of inflammatory diseases,especially for the treatment of chronic anemia that is inflammatory anemia,and should be further studied.There were 57 research papers cited.

关 键 词：异功散 活性成分 抗炎机制 核因子(NF)-κB通路 丝裂原活化蛋白激酶(MAPK)通路 

分 类 号：R285.6[医药卫生—中药学]