基于中医传承辅助系统挖掘三期辨证指导下中医治疗骨质疏松性骨折的用药规律  

Mining medication law of traditional Chinese medicine treatment of osteoporotic fracture under the guidance of three-stage syndrome differentiation based on traditional Chinese medicine inheritance support system

作　　者：杜梦凡 陈灿 陈一仁 郭双 赵宇 张燕[2] 刘俊宁 牛素生[2] DU Mengfan;CHEN Can;CHEN Yiren;GUO Shuang;ZHAO Yu;ZHANG Yan;LIU Junning;NIU Susheng(College of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China;Key Laboratory of Orthopedics&Traumatology and Rehabilitation of Traditional Chinese Medicine,Ministry of Education,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou350122,China)

机构地区：[1]福建中医药大学中医学院,福建福州350122 [2]福建中医药大学中医骨伤及运动康复教育部重点实验室,福建福州350122

出　　处：《中国医药导报》2023年第20期34-38,共5页China Medical Herald

基　　金：福建省卫生健康中青年骨干人才培养项目(2019-ZQN-73)。

摘　　要：目的 探讨中医三期辨证理论下中药治疗骨质疏松性骨折的用药规律,为临床治疗骨质疏松性骨折提供参考。方法 通过中国知网、万方数据库、维普网收集运用中药方剂治疗骨质疏松性骨折建库至2022年5月的相关文献,筛选、整理处方数据,并进行规范化处理,利用中医传承辅助系统(V 2.5)进行药物类别、性味归经、组方规律、熵聚类分析。结果 检索并去重后收录文章2 009篇,最终纳入早期方剂100首,中期95首,后期95首。骨质疏松性骨折早期使用频次最高的中药为红花,中期和后期使用频次最高的为当归和杜仲。在三期中使用药物的四气均以温、寒、平为主,五味均以甘、苦、辛为主;归经频次高的为肝、肾、脾、心经,演化得到6个常用药对和3个新组方。结论 临床治疗骨质疏松性骨折可根据三期辨证,灵活运用活血化瘀、止痛合营、补肝肾、益气血之药,提高中药治疗的效果。Objective To explore the medication rule of traditional Chinese medicine for osteoporotic fracture under the theory of three-stage syndrome differentiation,and to provide reference for clinical treatment of osteoporotic fracture.Methods Through CNKI,Wanfang Data,and VIP,literatures related to the use of traditional Chinese medicine prescriptions in the treatment of osteoporotic fractures from inception to May 2022 was collected,prescription data were screened and sorted out,and standardized processing was carried out.The traditional Chinese medicine inheritance support system system(V 2.5)was used to conduct drug classification,normalization of nature and flavour,formula composition rule,and entropy cluster analysis.Results After retrieval and removal,2009 articles were included,including 100 prescriptions in the early stage,95 in the middle stage,and 95 in the late stage.In the early stage of osteoporotic fracture,the most frequently used drug was Fos Carthami,and the most frequently used drugs were Radix Angelicae Sinensis and Cortex Eucommiae in the middle and late stage.In three-stage,the four nature of drugs were mainly warm,cold,clam,and the five flavour of drugs were mainly sweet,bitter,and pungent.Liver,kidney,spleen,and heart channels with high frequency of meridian conversion were developed,and six common drug pairs and three new prescriptions were obtained.Conclusion Clinical treatment of osteoporotic fracture can be based on the three-stage syndrome differentiation,flexible use the drugs of promoting blood circulation for removing blood stasis,relieving pain and harmonizing ying,nourishing liver and kidney,replenishing qi and blood,improve the effect of Chinese medicine treatment.

关 键 词：骨质疏松性骨折 三期辨证 数据挖掘 中医传承辅助系统 

分 类 号：R274.1[医药卫生—中医骨伤科学]